Inflammation in Children With Attention-Deficit/Hyperactivity Disorder (ADHD_CYTO)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified August 2006 by Tel-Aviv Sourasky Medical Center.
Recruitment status was  Not yet recruiting
Sponsor:
Information provided by:
Tel-Aviv Sourasky Medical Center
ClinicalTrials.gov Identifier:
NCT00391495
First received: October 22, 2006
Last updated: June 18, 2007
Last verified: August 2006

October 22, 2006
June 18, 2007
September 2007
Not Provided
Not Provided
  • To determine the inflammatory response in ADHD children by measuring
  • Serum CR-P levels, plasma cytokine levels and cytokine production by PBMC's (Peripheral Blood Mononuclear Cells).
Complete list of historical versions of study NCT00391495 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Inflammation in Children With Attention-Deficit/Hyperactivity Disorder
Inflammation in Children With Attention-Deficit/Hyperactivity Disorder

The aim of this study is to investigate the inflammatory response in children with this disorder.

Attention deficit-hyperactivity disorder (ADHD) is a prevalent childhood neuropsychiatric disorder, characterized by age-inappropriate and impairing levels of inattention, hyperactivity and impulsiveness. Approximately 5-10% of school-age children are affected by ADHD, and in many cases, symptoms persist into adolescence and adulthood.

Cytokines are key mediators of immune function and can be either pro-inflammatory or anti-inflammatory. Recently few studies have suggested involvement of cytokine pathways in subjects with ADHD.

Polymorphism of IL-1 receptors antagonists' alleles have been suggested in families and subjects suffering from ADHD. Moreover, a new variant of inflammatory bowel disease, another immunological based disease, was recently suggested in children with ADHD and other developmental disorders. There are no other published reports on cytokine production in children who suffer from ADHD.

Observational
Observational Model: Case Control
Time Perspective: Cross-Sectional
Not Provided
Not Provided
Not Provided
Not Provided
Attention-Deficit/Hyperactivity Disorder
Procedure: Blood drawing
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Not yet recruiting
45
December 2007
Not Provided

Inclusion Criteria:

  1. A defined condition of ADHD according to TOVA test (TOVA score > (-1.8), Connor's questionnaire (Connor's score > 15 points) and Achenbach's questionnaire;
  2. A consent form signed by parents or legal guardianships;

Exclusion Criteria:

  1. A history of any other neurological or major psychiatric disorder or other significant medical problems;
  2. No current medications;
Both
9 Years to 13 Years
Yes
Contact: Nachum Vaisman, Prof. (MD) 972-3-6974807 vaisman@tasmc.health.gov.il
Israel
 
NCT00391495
TASMC-06-NV-246-CTIL
Yes
Not Provided
Tel-Aviv Sourasky Medical Center
Not Provided
Principal Investigator: Nachum Vaisman, Prof. (MD) Tel-Aviv Sourasky Medical Center
Tel-Aviv Sourasky Medical Center
August 2006

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP