Intravitreal Bevacizumab for Neovascular Glaucoma (IVB NVG)

This study has been completed.
Sponsor:
Information provided by:
Shahid Beheshti Medical University
ClinicalTrials.gov Identifier:
NCT00384631
First received: October 4, 2006
Last updated: February 14, 2008
Last verified: February 2008

October 4, 2006
February 14, 2008
April 2006
Not Provided
  • Change in intraocular pressure [ Time Frame: 6 months ]
  • Change in extent of iris neovascularization [ Time Frame: 6 months ]
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Complete list of historical versions of study NCT00384631 on ClinicalTrials.gov Archive Site
Best corrected visual acuity [ Time Frame: 6 months ]
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Intravitreal Bevacizumab for Neovascular Glaucoma
Intravitreal Bevacizumab for Neovascular Glaucoma; a Randomized Placebo Controlled Clinical Trial

Several studies have confirmed high levels of vascular endothelial growth factor (VEGF) in eyes with neovascular glaucoma (NVG). The role of VEGF inhibitors in regression of other neovascular disorders such as wet-type age-related macular degeneration and diabetic macular edema has been described. We aim to evaluate the effect of three intravitreal injections of bevacizumab (Avastin) 2.5 mg versus a sham procedure for treatment of NVG. Outcome measures include intraocular pressure and extent of iris neovascularization. Both study arms will receive conventional treatment for NVG.

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Interventional
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Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Outcomes Assessor)
Primary Purpose: Treatment
  • Neovascular
  • Glaucoma
  • Other: subconjunctival normal saline
    0.1cc normal saline injection in the subconjunctival space repeated twice at monthly intervals
  • Drug: Avastin
    intravitreal injection of avastin 2.5mg repeated twice at monthly intervals
  • Sham Comparator: 2
    Intervention: Other: subconjunctival normal saline
  • Experimental: 1
    Intervention: Drug: Avastin
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
26
March 2007
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Inclusion Criteria:

  • Clinical diagnosis of NVG
  • Vision less than 20/200
  • age 10-80 years

Exclusion Criteria:

  • Uncontrolled Blood Pressure
  • History of thromboembolism
  • Congestive Heart Failure
  • Renal Failure
  • Pregnancy or Lactation
  • Active ocular or periocular infection
  • No light perception
Both
10 Years to 80 Years
No
Contact information is only displayed when the study is recruiting subjects
Iran, Islamic Republic of
 
NCT00384631
8414
Yes
Not Provided
Shahid Beheshti Medical University
Not Provided
Principal Investigator: Shahin Yazdani, MD Ophthalmic Research Center, Shaheed Beheshti Medical University
Shahid Beheshti Medical University
February 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP