This study will evaluate the differences in smoking behavior, nicotine intake, and nicotine boost among people with schizophrenia, bipolar disorder, or no mental illness.

People with schizophrenia, a disabling mental disorder, smoke at rates three times higher than those of the general population. They also tend to develop serious medical problems due to this heavy smoking. Little is known, however, about the relationship between schizophrenia and smoking. Smoking topography, the study of cigarette-puffing behavior, may help to uncover important information about the smoking habits of people with schizophrenia, and how they differ from smokers who do not have a mental illness. To develop more effective treatment approaches for schizophrenic smokers, a better understanding of nicotine addiction in this population is needed. This study will use hand-held smoking topography devices and blood tests to measure smoking behavior and nicotine levels in people with schizophrenia. This information will be compared to similar measurements in people with no mental illness and in people with bipolar disorder, another disorder associated with high rates of heavy smoking.

Participation in this open-label, observational study will last approximately 1 to 2 weeks, and will consist of two to three study visits. The first visit will last about 2 hours, and will include screening procedures, completion of baseline questionnaires, and a practice session of smoking topography. Subjects will return on a second day (Day 2) for the remainder of the study procedures to assess their smoking puffing behavior and nicotine intake from usual cigarette smoking, which will occur within 1 week of the Day 1 assessments. On the afternoon prior to Day 2 subjects will have a brief appointment to review instructions for using the topography device. They will take the topography with them and be instructed to use it as they smoke ad-lib that evening at home. This will serve as a second practice session for getting used to the topography device. They will also be instructed to use the device for all cigarettes smoked upon awakening the next day at 6am (Day 2), including the first cigarette of the day. They will go to the study site for the first of three blood tests at 9:30 A.M, after which they will be allowed to leave the study site to continue with their daily activities. They will use the smoking topography device throughout the day, until 3 P.M. At this time, study staff will go to each participant's location to collect the device. Participants will have two additional blood tests over the course of the study to measure nicotine levels.

Inclusion Criteria:

For smokers with schizophrenia or bipolar disorder:

• Meets DSM-IV diagnostic criteria for schizophrenia or bipolar I disorder
• Smokes 10 or more cigarettes every day
• Has been stable on current psychiatric medications for at least 1 month prior to study entry

For control smokers without mental illness:

• Smokes 10 or more cigarettes every day

Exclusion Criteria:

For smokers with schizophrenia or bipolar disorder:

• Current or past suicidal ideation, behavior, or suicide attempt within 30 days prior to study entry
• Psychiatric hospitalization within 30 days prior to study entry
• Inability to read English or inability to sufficiently understand study documents written in English
• Pregnant, breastfeeding, or plans to become pregnant within 1 month of study entry
• Current use of any non-cigarette forms of tobacco (e.g., cigars, pipes, smokeless tobacco, or ultralight cigarettes)
• Current substance abuse problem, as defined by DAST or AUDIT criteria
• Significant cognitive impairment that may interfere with study participation, as defined by a Folstein Mini-Mental Status exam score of less than 22

For control smokers without mental illness:

• Any DSM-defined mental disorder within 1 year prior to study entry
• Inability to read English or inability to sufficiently understand study documents written in English
• Concomitant use of nicotine replacement therapy (e.g., gum, patch, inhaler, nasal spray, or lozenge), clonidine, bupropion, or nortriptyline
• Pregnant, breastfeeding, or plans to become pregnant within 1 month of study entry
• Current use of any non-cigarette forms of tobacco (e.g., cigars, pipes, smokeless tobacco, or ultralight cigarettes)
• Diagnosis or treatment for an episode of any mental disorder (e.g., depression or anxiety) within 1 year prior to study entry
• Lifetime diagnosis of bipolar disorder or schizophrenia
• Lifetime history of any psychotic symptoms
• Lifetime use of antipsychotic medication for any reason
• Use of any antidepressants, mood stabilizers, or anti-anxiety medications for any reason within 6 months prior to study entry
• Current substance abuse problem, as defined by DAST or AUDIT criteria