Physical Activity After Stroke: How Does it Effect Chronical Inflammation and Insulin Sensitivity

This study has been completed.
Sponsor:
Information provided by:
Bispebjerg Hospital
ClinicalTrials.gov Identifier:
NCT00376207
First received: September 13, 2006
Last updated: October 16, 2007
Last verified: October 2007

September 13, 2006
October 16, 2007
January 2006
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  • Association between PASE and HOMA
  • Association between PASE and IL-6
Same as current
Complete list of historical versions of study NCT00376207 on ClinicalTrials.gov Archive Site
  • IL-6 concentration is lower in the intervention group than control group.
  • TNF-alfa and IL-6 is positively associated.
  • IL-18 is associated to HOMA
  • Correlation between PASE and HOMA in the intervention group vs. controls
  • HOMA mean value in the 2 groups
Same as current
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Physical Activity After Stroke: How Does it Effect Chronical Inflammation and Insulin Sensitivity
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Decreased insulin sensitivity is and independent risk factor for stroke despite glycemic control. It is known that physical exercise increases insulin sensitivity in healthy subjects. Wether stroke patients can increase insulin sensitivity via physical exercise is not known.

Chronic low-grade inflammation is associated with an increased risk of stroke. Physical exercise has shown to increase IL-6 directly after exercise in untrained subjects. When fitness is increased in each subject then the peak IL-6 concentration after exercise decreases and so does the basal level of IL-6. It is not known whether stroke patients can increase physical activity level to a degree where chronic inflammation are decreased.

This study is designed to evaluate if physical exercise after stroke will increases insulin sensitivity and reduce low-grade chronic inflammation.

Stroke patients have been randomized to intervention with physical exercise or control in the ExStroke pilot trial and followed for 2 years. Using the study population from the ExStroke pilot trail blood samples will be obtained at the last control. Insulin sensitivity can be measured from fasting glucose and insulin using the Homeostasis Model Assessment (HOMA). Interleukin-6, TNF-alfa and CRP is measured to estimate chronic inflammation.

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Interventional
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Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single Blind
Primary Purpose: Prevention
Cerebral Infarction
Behavioral: Physical exercise
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
200
August 2007
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Inclusion Criteria:

  • participated in the ExStroke Pilot trail

Exclusion Criteria:

  • Diabetes Mellitus
  • Not able to give informed consent
Both
40 Years and older
No
Contact information is only displayed when the study is recruiting subjects
Denmark
 
NCT00376207
LK-0102200601
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Bispebjerg Hospital
Not Provided
Principal Investigator: Lars-Henrik Krarup, MD Bispebjerg Hospital
Bispebjerg Hospital
October 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP