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Study of the Relationship Between Blood Vessels and Insulin Response in Adolescents

This study has been completed.
Sponsor:
Collaborator:
Nationwide Children's Hospital
Information provided by:
Ohio State University
ClinicalTrials.gov Identifier:
NCT00374361
First received: September 7, 2006
Last updated: September 8, 2006
Last verified: September 2006

September 7, 2006
September 8, 2006
July 2003
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Complete list of historical versions of study NCT00374361 on ClinicalTrials.gov Archive Site
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Study of the Relationship Between Blood Vessels and Insulin Response in Adolescents
Relationship of Endothelial Function to Insulin Sensitivity in African American and Caucasian Adolescents

This study is designed to determine whether there is a relationship between the way insulin and blood vessels work. The difference in the interaction between Caucasian and African American adolescents will also be examined. This may play a role in the differing rates of heart disease and diabetes between the two groups.

Purpose: The purpose of the research is to learn more about how the lining of arteries in the body (called the endothelium) and insulin work in adolescents. Abnormalities in how the blood vessels and insulin work in adolescents may cause high blood pressure, type 2 diabetes, stroke and heart disease.

Healthy adolescents between 8 and 18 years of age are being studied in the Ohio State University General Clinical Research Center. Two visits will be necessary. One will be a screening visit to determine the child's stage of puberty and obtain a medical history. The second will be the study visit. During the latter, blood vessel function will be determined by studying the change in forearm blood flow before and after blood flow to the forearm is stopped. Insulin sensitivity will be determined using glucose water given into a vein.

Observational
Observational Model: Defined Population
Time Perspective: Cross-Sectional
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  • Diabetes Mellitus, Type 2
  • Hypertension
  • Heart Disease
  • Stroke
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
66
June 2006
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Inclusion Criteria:

  • Caucasian or African American adolescent
  • Between 8 and 18 years of age

Exclusion Criteria:

  • Pregnancy
  • Chronic Disease
  • Acute Disease
  • Medication Requirement
Both
8 Years to 18 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00374361
ENDO 203, AHA 0355195B
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Ohio State University
Nationwide Children's Hospital
Study Chair: Robert P Hoffman, MD Ohio State University
Ohio State University
September 2006

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP