Molecular Epidemiology of Benzene-exposed Workers.
This study has been completed.
Sponsor:
University of Colorado, Denver
Collaborators:
Fudan University
University of Cincinnati
ExxonMobil Biomedical Sciences, Inc.
British Petroleum-Amoco
Chevron
ConocoPhillips
Exxon Mobil
Marathon Ashland
Shell Chemicals
Information provided by (Responsible Party):
University of Colorado, Denver
ClinicalTrials.gov Identifier:
NCT00364520
First received: August 14, 2006
Last updated: February 5, 2013
Last verified: May 2007
| Tracking Information | |||||
|---|---|---|---|---|---|
| First Received Date ICMJE | August 14, 2006 | ||||
| Last Updated Date | February 5, 2013 | ||||
| Start Date ICMJE | August 2003 | ||||
| Primary Completion Date | December 2009 (final data collection date for primary outcome measure) | ||||
| Current Primary Outcome Measures ICMJE |
Investigate the dose-response relationship between benzene exposure and blood diseases in Shanghai workers. [ Time Frame: August 2003 - December 2009 ] [ Designated as safety issue: No ] Investigate the dose-response relationship between benzene exposure and blood diseases in Shanghai workers |
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| Original Primary Outcome Measures ICMJE | Not Provided | ||||
| Change History | Complete list of historical versions of study NCT00364520 on ClinicalTrials.gov Archive Site | ||||
| Current Secondary Outcome Measures ICMJE |
Characterize genetic polymorphisms that are associated with increased risk of developing benzene hematotoxicity. [ Time Frame: August 2003 - December 2009 ] [ Designated as safety issue: No ] Characterize genetic polymorphisms that are associated with increased risk of developing benzene hematotoxicity. |
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| Original Secondary Outcome Measures ICMJE | Not Provided | ||||
| Current Other Outcome Measures ICMJE | Not Provided | ||||
| Original Other Outcome Measures ICMJE | Not Provided | ||||
| Descriptive Information | |||||
| Brief Title ICMJE | Molecular Epidemiology of Benzene-exposed Workers. | ||||
| Official Title ICMJE | Molecular Epidemiology of Benzene-exposed Workers in Shanghai,China | ||||
| Brief Summary | The purpose of this study is to investigate the health effects of benzene exposure in workers in Shanghai, China. |
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| Detailed Description | The purpose of this study is to investigate the dose-response relationship between benzene exposure and blood diseases in Shanghai workers and to characterize genetic polymorphisms that are associated with increased risk of developing benzene hematotoxicity. |
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| Study Type ICMJE | Observational | ||||
| Study Design ICMJE | Observational Model: Ecologic or Community Time Perspective: Cross-Sectional |
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| Target Follow-Up Duration | Not Provided | ||||
| Biospecimen | Not Provided | ||||
| Sampling Method | Non-Probability Sample | ||||
| Study Population | Shanghai Workers |
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| Condition ICMJE | Hematologic Diseases | ||||
| Intervention ICMJE | Other: Shanghai workers | ||||
| Study Group/Cohort (s) | Shanghai Workers
Shanghai Workers
Intervention: Other: Shanghai workers |
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| Publications * | Not Provided | ||||
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* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline. |
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| Recruitment Information | |||||
| Recruitment Status ICMJE | Completed | ||||
| Enrollment ICMJE | 2000 | ||||
| Completion Date | December 2009 | ||||
| Primary Completion Date | December 2009 (final data collection date for primary outcome measure) | ||||
| Eligibility Criteria ICMJE | Inclusion Criteria: Worked for at least one year in a monitored environment Have at least one physical examination recorded - Exclusion Criteria: History of cancer, radiation exposure, chemotherapy - |
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| Gender | Both | ||||
| Ages | 18 Years to 67 Years | ||||
| Accepts Healthy Volunteers | Yes | ||||
| Contacts ICMJE | Contact information is only displayed when the study is recruiting subjects | ||||
| Location Countries ICMJE | China | ||||
| Administrative Information | |||||
| NCT Number ICMJE | NCT00364520 | ||||
| Other Study ID Numbers ICMJE | 02-037 | ||||
| Has Data Monitoring Committee | No | ||||
| Responsible Party | University of Colorado, Denver | ||||
| Study Sponsor ICMJE | University of Colorado, Denver | ||||
| Collaborators ICMJE |
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| Investigators ICMJE |
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| Information Provided By | University of Colorado, Denver | ||||
| Verification Date | May 2007 | ||||
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ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP |
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