Atrial Fibrillation and the Risk for Neurological Complications

The recruitment status of this study is unknown because the information has not been verified recently.
Verified April 2007 by University Hospital Muenster.
Recruitment status was  Recruiting
Sponsor:
Collaborator:
German Federal Ministry of Education and Research
Information provided by:
University Hospital Muenster
ClinicalTrials.gov Identifier:
NCT00357227
First received: July 25, 2006
Last updated: April 18, 2007
Last verified: April 2007

July 25, 2006
April 18, 2007
January 2004
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Complete list of historical versions of study NCT00357227 on ClinicalTrials.gov Archive Site
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Atrial Fibrillation and the Risk for Neurological Complications
Atrial Fibrillation and the Risk for Neurological Complications

B8: Atrial fibrillation and the risk of neurological complications

Twenty-five thousand acute strokes are caused by atrial fibrillation every year. But even more frequent than symptomatic strokes are silent infarctions of the brain. Silent strokes remain undetected in most cases, but cumulate over time and progressively impair cognition. The impact of atrial fibrillation on subacute brain infarctions is not yet known. Moreover, it has not been elucidated so far how effective different therapeutic strategies in the treatment of atrial fibrillation prevent cognitive impairment. Thus, this study aims at evaluating the influence of different types of atrial fibrillation on silent strokes and the related impairment in cognitive functions. Other risk factors and cardiovascular diseases that are known to provoke the development of strokes will be assessed as well. So, it will be possible to isolate the contribution of atrial fibrillation to silent strokes and related cognitive impairment in segregation to other relevant factors. AF patients and controls will be examined twice in two years in order to evaluate the role of atrial fibrillation and differential therapeutic interventions with regard to the progression of silent strokes and cognitive impairment in a within subject-design.

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Observational
Observational Model: Defined Population
Time Perspective: Longitudinal
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Atrial Fibrillation
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
1000
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Inclusion Criteria:

  • Clinical diagnosis of permanent, paroxysmal or episodic atrial fibrillation in the past or at present

Exclusion Criteria:

  • Pacemaker
  • Metal implants
  • History of acute stroke
  • Diagnosis of vascular or degenerative dementia
  • History of brain tumors
  • History of severe brain injury
  • History of psychiatric disorders
  • Pregnancy
Both
50 Years to 85 Years
Yes
Contact: Stefan Knecht, Prof. +49-251-83- ext 48195 knecht@uni-muenster.de
Germany
 
NCT00357227
01 GI 0204
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University Hospital Muenster
German Federal Ministry of Education and Research
Principal Investigator: Stefan Knecht, Prof. University Hospital Münster, Department of Neurology
University Hospital Muenster
April 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP