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Attention and Visual Perception in Schizophrenia: A Functional Magnetic Resonance Imaging (fMRI) Study

This study has been completed.
Sponsor:
Collaborators:
Institut National de la Santé Et de la Recherche Médicale, France
France: Centre National de la Recherche Scientifique
Région Alsace
Faculté de Médecine de Strasbourg
Information provided by:
University Hospital, Strasbourg, France
ClinicalTrials.gov Identifier:
NCT00350935
First received: July 10, 2006
Last updated: June 25, 2010
Last verified: June 2010
History of Changes

July 10, 2006
June 25, 2010
September 2006
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Complete list of historical versions of study NCT00350935 on ClinicalTrials.gov Archive Site
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Attention and Visual Perception in Schizophrenia: A Functional Magnetic Resonance Imaging (fMRI) Study
Attention and Grouping of Visual Information: What is Disturbed in Patients With Schizophrenia?

The main objective of the study is to contribute to a better understanding of the physiopathology of schizophrenia, by studying causal relationships between cognitive deficits and the neurobiological basis for these deficits. Processing visual information involves both automatic grouping processes and control processes. Automatic grouping processes allow the building of a global configuration from local contour information. It is necessary in order to recognize objects. Control processes allow tending to and prioritizing information parts. The paradigm the investigators use allows to dissociate these processes, and is used in order to characterize the impairments observed in patients with schizophrenia. It is adapted to fMRI in order to explore the neurobiological basis of the deficits. The investigators will examine whether functional disconnectivity between activated areas subtend the impairments observed in patients.
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Observational
Observational Model: Case Control
Time Perspective: Prospective
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Non-Probability Sample

Primary care clinic, residents of Strasbourg
Schizophrenia
Procedure: fMRI
One 30 minute session
  • Healthy volunteers
    Healthy controls
    Intervention: Procedure: fMRI
  • Patients
    Patients with schizophrenia
    Intervention: Procedure: fMRI
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
52
April 2009
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Inclusion Criteria:

  • Patients with schizophrenia (DSM-IV criteria)
  • Healthy controls matched with patients on age, sex and education level
  • Ages 18 to 50
  • Signed informed consent
  • Right-handed

Exclusion Criteria:

  • No severe somatic illness
  • No invalidating sensory disease
  • No drug abuse, as defined by DSM-IV criteria
  • No general anaesthesia in the past 3 months
  • No intake of drugs affecting the CNS, except for patients
Both
18 Years to 50 Years
Yes
Contact information is only displayed when the study is recruiting subjects
France
 
NCT00350935
3456
Not Provided
Emmanuel LAVOUE, Directeur Adjoint de la DRCI, University Hospital, Strasbourg, France
University Hospital, Strasbourg, France
  • Institut National de la Santé Et de la Recherche Médicale, France
  • France: Centre National de la Recherche Scientifique
  • Région Alsace
  • Faculté de Médecine de Strasbourg
Principal Investigator: Anne Giersch, MD Institut National de la Santé Et de la Recherche Médicale, France
University Hospital, Strasbourg, France
June 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP