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| Descriptive Information Fields | |||||||||
| Brief Title † | An fMRI Study of Self-Regulation in Adolescents With Bulimia Nervosa | ||||||||
| Official Title † | An fMRI Study of Self-Regulation in Adolescents With Bulimia Nervosa | ||||||||
| Brief Summary | The aim of this project is to use both functional MRI (fMRI) and behavioral measures to investigate how disturbances in frontostriatal neural systems contribute to the impulsive and habitual binge-eating behaviors in patients with Bulimia Nervosa (BN). Findings from this study will have wide-ranging importance for our understanding of the development and treatment of BN. |
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| Detailed Description | Patients with Bulimia Nervosa (BN) have difficulty regulating impulsive behaviors as suggested by their binge-eating and purging, as well as the high incidence of drug abuse and shoplifting in this population. Understanding dysfunction in the frontostriatal circuitry that mediates self-regulatory control processes will aid development of new therapeutics for the impulsivity associated with BN. Thus we aim to use fMRI and neuropsychological measures to investigate the functioning of frontostriatal systems and self-regulatory control processes in adolescents with BN. Participation in this study includes 4 sections: Neuropsychological Tests, Diagnostic interviews, Pregnancy Test, and MRI scan. All efforts are made to coordinate procedures into one day, and they require between 4 and 5 hours of the participant's time. The option of splitting participation into two study days is also offered for participants who find it more convenient. Participants are compensated with $100 in the form of a check, which is mailed to their home address. |
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| Study Phase | |||||||||
| Study Type † | Observational | ||||||||
| Study Design † | Case Control, Prospective | ||||||||
| Primary Outcome Measure † | Functional magnetic resonance imaging scan [ Time Frame: Measured at a single visit ] [ Designated as safety issue: No ] | ||||||||
| Secondary Outcome Measure † | Wechsler Abbreviated Scale of Intelligence (WASI) [ Time Frame: Measured at a single visit ] [ Designated as safety issue: No ] Continuous Performance Task [ Time Frame: Measured at a single visit ] [ Designated as safety issue: No ] Rotary Pursuit [ Time Frame: Measured at a single visit ] [ Designated as safety issue: No ] Mirror Tracing [ Time Frame: Measured at a single visit ] [ Designated as safety issue: No ] Stroop Word-Color Interference [ Time Frame: Measured at a single visit ] [ Designated as safety issue: No ] Weather Prediction Task [ Time Frame: Measured at a single visit ] [ Designated as safety issue: No ] |
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| Condition † | Eating Disorders | ||||||||
| Intervention † | Other: fMRI Behavioral: Neuropsychological Testing |
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| MEDLINE PMIDs | |||||||||
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| Recruitment Information Fields | |||||||||
| Recruitment Status † | Recruiting | ||||||||
| Enrollment † | 80 | ||||||||
| Start Date † | November 2004 | ||||||||
| Completion Date | November 2010 | ||||||||
| Eligibility Criteria † | Inclusion Criteria:
Exclusion Criteria:
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| Gender | Female | ||||||||
| Ages | 12 Years to 21 Years | ||||||||
| Accepts Healthy Volunteers | Yes | ||||||||
| Contacts †† |
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| Location Countries † | United States | ||||||||
| Administrative Information Fields | |||||||||
| NCT ID † | NCT00345943 | ||||||||
| Organization ID | K01 MH77652 | ||||||||
| Secondary IDs †† | |||||||||
| Study Sponsor † | National Institute of Mental Health (NIMH) | ||||||||
| Collaborators †† | |||||||||
| Investigators † |
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| Information Provided By | National Institute of Mental Health (NIMH) | ||||||||
| Verification Date | August 2008 | ||||||||
| First Received Date † | June 28, 2006 | ||||||||
| Last Updated Date | August 8, 2008 | ||||||||
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