Psychopathology of Normal-tension Glaucoma in Hong Kong Chinese Out-patient

The recruitment status of this study is unknown because the information has not been verified recently.
Verified August 2009 by Chinese University of Hong Kong.
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by:
Chinese University of Hong Kong
ClinicalTrials.gov Identifier:
NCT00324181
First received: May 8, 2006
Last updated: August 3, 2009
Last verified: August 2009

May 8, 2006
August 3, 2009
June 2006
June 2010   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT00324181 on ClinicalTrials.gov Archive Site
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Psychopathology of Normal-tension Glaucoma in Hong Kong Chinese Out-patient
Psychopathology of Normal-tension Glaucoma in Hong Kong Chinese Out-patient

It is suggested the pathogenesis of normal-tension glaucoma (NTG) involves vascular dysregulation. In the past studies, it is well documented that many physical problems related to vascular dysregulation, such as angina pectoris (Friedman M et al 1974; Russek HI et al 1976), migraine (Diener HC et al 1994), primary Raynaud's disease (Wagner HH et al 1993) and stroke (Gainotti G, et al, 2001; Hayee Ma et al 2001), are associated with a high risk of depressive illness. So, NTG, being a disease involving vascular dysregulation, is postulated to be associated with psychopathology.

Glaucoma increases after 40 year-old and the number of people over this age in Hong Kong is rapidly growing. However, we have no knowledge about the link between psychopathology and NTG in Hong Kong. The present study is sought to overcome the limitation in previous research and the goals of present study are:

  • To identify the prevalence of psychopathology of normal-tension glaucoma Hong Kong Chinese Out-patients attending a university-affiliated glaucoma clinic.
  • To determine whether there are any differences among NTG patients, patients with glaucoma other than NTG and control in terms of psychopathology and quality of life.

Designs:

Case-control study to compare among patients with normal-tension glaucoma (NTG), patients with glaucoma other than normal-tension glaucoma (OTNTG) and control in terms of psychopathology and quality of life

Patients with chronic medical illness have been shown to have higher rates of depression and other psychopathology (Kimmel PL et al, 1998; Amato L et al, 1996). Glaucoma is a chronic, progressive ophthalmologic disease. Treatment may involve the use of multiple medications and surgery. Despite therapy, many patients continue to worsen, and some may even lose vision. Because of this threat of potential loss of vision and the known depression-related side effects of some of topical glaucoma medication, particular beta-blocker (Cove-Smith JR et al, 1985), it can be necessary hypothesized that glaucoma patient may have an increased prevalence of depression and other psychopathology. It is also reasonable to apply similar hypothesis on the patients with normal-tension glaucoma.

Normal-tension glaucoma (NTG) is a type of open-angle glaucoma defined as an optic neuropathy with visual-field defects together normal distribution of intraocular pressure (<21 mmHg) over a period of twenty-four hour as well as normal chamber-angle anatomy (Levene RZ, 1980). NTG is associated with different vasospastic syndrome including higher incidence of migraine (Phelps CD et al, 1985), angina pectoris (Goldberg I et al, 1981), silent myocardial ischemia (Kaiser HJ et al, 1993) and ocular vasopasm (Flammer J et al, 1991; Flammer J et al 1987; Orgul S et al 1995). Such associated clinical characteristics suggest that the pathogenesis of NTG involves vascular dysregulation. In the past studies, it is well documented that many physical problems related to vascular dysregulation, such as angina pectoris (Friedman M et al 1974; Russek HI et al 1976), migraine (Diener HC et al 1994), primary Raynaud's disease (Wagner HH et al 1993) and stroke (Gainotti G, et al, 2001; Hayee Ma et al 2001), are associated with a high risk of depressive illness. So, NTG, being a disease involving vascular dysregulation, is postulated to be associated with psychopathology.

Observational
Observational Model: Cohort
Time Perspective: Prospective
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Non-Probability Sample

Glaucoma patients from a tertiary University Ophthalmic clinic setting

Glaucoma
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
100
June 2010
June 2010   (final data collection date for primary outcome measure)

Inclusion Criteria:

Inclusion criteria of patients (NTG and OTNTG):

  • Cantonese-speaking Chinese
  • Aged from 18 to 65
  • Attending university-affiliated glaucoma clinic from August, 2005 to June, 2006 with written consent Inclusion criteria of control
  • Those just receiving routine fundi examination without any ophthalmologic follow-up afterwards
  • Cantonese-speaking Chinese
  • Aged from 18 to 65
  • With written consent

Exclusion Criteria of cases:

Exclusion criteria:

  • Psychoses
  • Psychiatric condition warranting hospitalization Exclusion criteria of control
  • Previous or current ocular or general acute or chronic disease
  • Taking any medication
  • Psychoses
  • Psychiatric condition warranting hospitalization
Both
18 Years to 65 Years
Yes
Contact information is only displayed when the study is recruiting subjects
China
 
NCT00324181
CRE-2006.060
Yes
Dexter Yu-lung LEUNG/ Honorary Clinical Assistant Professor, DOVS, CUHK
Chinese University of Hong Kong
Not Provided
Principal Investigator: Karina Chan, MBChB, MRCPsych Department of Psychiatry, Kowloon Hospital, Hong Kong
Study Director: Dexter Leung, MBChB, FRCS Chinese University of Hong Kong
Study Director: Sing Lee, MD, MRCPsych Department of Psychiatry, CUHK
Study Chair: Dennis Lam, MD, FRCOphth Chinese University of Hong Kong
Chinese University of Hong Kong
August 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP