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| Descriptive Information Fields | |||||||||
| Brief Title † | Cognitive Behavioral Therapy Plus Motivational Interviewing for Treatment of Obsessive-Compulsive Disorder | ||||||||
| Official Title † | Cognitive Behavioral Therapy Plus Motivational Interviewing for Obsessive Compulsive Disorder | ||||||||
| Brief Summary | This study will determine the effectiveness of adding motivational interviewing to cognitive behavioral therapy, consisting of exposure and ritual prevention, in improving treatment outcomes in people with obsessive-compulsive disorder. |
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| Detailed Description | Obsessive Compulsive Disorder (OCD) is a chronic and debilitating anxiety disorder. People with OCD often experience recurrent unwanted thoughts, or obsessions. Some examples of obsessions include the following: repetitive fears of causing harm or being harmed; fears of contamination and illness; fears of making mistakes; intrusive distressing sexual or religious imagery; and fears of losing things. In an effort to relieve anxiety about these obsessions, people with OCD develop repetitive behaviors called compulsions. Some examples of compulsions include the following: repetitive washing and cleaning; excessive checking; excessive ordering and arranging; and extreme hoarding and saving. These thoughts and behaviors interfere with everyday life to a great extent. Cognitive behavior therapy (CBT) with exposure and ritual prevention (EX/RP) is a standard treatment for OCD. EX/RP involves both imaginary and real exposure to situations or settings that may stimulate OCD behavior, and it requires that patients refrain from ritualizing. Motivational interviewing (MI) may help to enhance an individual's motivation to change by exploring and resolving ambivalence. This study will determine the effectiveness of adding MI to CBT that consists of EX/RP in improving treatment outcome in people with OCD. Participants in this single-blind study will be randomly assigned to receive either standard CBT with EX/RP or CBT with EX/RP plus MI. All participants will report to the study site twice weekly for both therapy and assessments for a total of 2 months. Assessments will include interviews and self-rating forms. No medication will be administered during this study. However, participants will continue on any medication that they are taking at the time of study entry. All participants will be assessed for outcomes upon study completion. Participants who respond to therapy will be assessed again 6 months following study completion. |
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| Study Phase | Phase I | ||||||||
| Study Type † | Interventional | ||||||||
| Study Design † | Treatment, Randomized, Single Blind (Outcomes Assessor), Active Control, Parallel Assignment, Efficacy Study | ||||||||
| Primary Outcome Measure † | Obsessive-compulsive symptoms [ Time Frame: Measured at Months 2 and 8 ] [ Designated as safety issue: No ] | ||||||||
| Secondary Outcome Measure † | Adherence, depression, insight, and quality of life [ Time Frame: Measured at Months 2 and 8 ] [ Designated as safety issue: No ] | ||||||||
| Condition † | Obsessive-Compulsive Disorder | ||||||||
| Intervention † | Behavioral: Motivational interviewing plus exposure and response prevention (MI plus EX/RP) Behavioral: Exposure and response prevention (EX/RP) |
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| MEDLINE PMIDs | |||||||||
| Links | Click here for the Obsessive-Compulsive Disorder Research Clinic website.  |
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| Recruitment Information Fields | |||||||||
| Recruitment Status † | Recruiting | ||||||||
| Enrollment † | 34 | ||||||||
| Start Date † | March 2006 | ||||||||
| Completion Date | March 2009 | ||||||||
| Eligibility Criteria † | Inclusion Criteria:
Exclusion Criteria:
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| Gender | Both | ||||||||
| Ages | 18 Years to 70 Years | ||||||||
| Accepts Healthy Volunteers | No | ||||||||
| Contacts †† |
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| Location Countries † | United States | ||||||||
| Administrative Information Fields | |||||||||
| NCT ID † | NCT00316316 | ||||||||
| Organization ID | R34 MH71570 | ||||||||
| Secondary IDs †† | DAHBR 96-BHA | ||||||||
| Study Sponsor † | National Institute of Mental Health (NIMH) | ||||||||
| Collaborators †† | |||||||||
| Investigators † |
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| Information Provided By | National Institute of Mental Health (NIMH) | ||||||||
| Verification Date | February 2008 | ||||||||
| First Received Date † | April 18, 2006 | ||||||||
| Last Updated Date | February 29, 2008 | ||||||||
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