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Cognitive Behavioral Therapy Plus Motivational Interviewing for Treatment of Obsessive-Compulsive Disorder

This study has been completed.
Sponsor:
Collaborator:
Information provided by (Responsible Party):
New York State Psychiatric Institute
ClinicalTrials.gov Identifier:
NCT00316316
First received: April 18, 2006
Last updated: March 15, 2012
Last verified: March 2012

April 18, 2006
March 15, 2012
March 2006
March 2010   (final data collection date for primary outcome measure)
Obsessive-compulsive symptoms [ Time Frame: Measured at Months 2 and 8 ] [ Designated as safety issue: No ]
Measured at Months 2 and 8: Obsessive-compulsive symptoms
Complete list of historical versions of study NCT00316316 on ClinicalTrials.gov Archive Site
Adherence, depression, insight, and quality of life [ Time Frame: Measured at Months 2 and 8 ] [ Designated as safety issue: No ]
Measured at Months 2 and 8: Adherence, depression, insight, and quality of life
Not Provided
Not Provided
 
Cognitive Behavioral Therapy Plus Motivational Interviewing for Treatment of Obsessive-Compulsive Disorder
Cognitive Behavioral Therapy Plus Motivational Interviewing for Obsessive Compulsive Disorder

This study will determine the effectiveness of adding motivational interviewing to cognitive behavioral therapy, consisting of exposure and ritual prevention, in improving treatment outcomes in people with obsessive-compulsive disorder.

Obsessive Compulsive Disorder (OCD) is a chronic and debilitating anxiety disorder. People with OCD often experience recurrent unwanted thoughts, or obsessions. Some examples of obsessions include the following: repetitive fears of causing harm or being harmed; fears of contamination and illness; fears of making mistakes; intrusive distressing sexual or religious imagery; and fears of losing things. In an effort to relieve anxiety about these obsessions, people with OCD develop repetitive behaviors called compulsions. Some examples of compulsions include the following: repetitive washing and cleaning; excessive checking; excessive ordering and arranging; and extreme hoarding and saving. These thoughts and behaviors interfere with everyday life to a great extent. Cognitive behavior therapy (CBT) with exposure and ritual prevention (EX/RP) is a standard treatment for OCD. EX/RP involves both imaginary and real exposure to situations or settings that may stimulate OCD behavior, and it requires that patients refrain from ritualizing. Motivational interviewing (MI) may help to enhance an individual's motivation to change by exploring and resolving ambivalence. This study will determine the effectiveness of adding MI to CBT that consists of EX/RP in improving treatment outcome in people with OCD.

Participants in this single-blind study will be randomly assigned to receive either standard CBT with EX/RP or CBT with EX/RP plus MI. All participants will report to the study site twice weekly for both therapy and assessments for a total of 2 months. Assessments will include interviews and self-rating forms. No medication will be administered during this study. However, participants will continue on any medication that they are taking at the time of study entry. All participants will be assessed for outcomes upon study completion. Participants who respond to therapy will be assessed again 6 months following study completion.

Interventional
Phase 1
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
Obsessive-Compulsive Disorder
  • Behavioral: Motivational interviewing plus exposure and response prevention (MI plus EX/RP)
    Participants will receive 18 sessions of MI plus EX/RP.
    Other Name: MI plus EX/RP
  • Behavioral: Exposure and response prevention (EX/RP)
    Participants will receive 18 sessions of EX/RP.
    Other Name: EX/RP
  • Active Comparator: 1
    Participants will receive motivational interviewing plus exposure and response prevention
    Intervention: Behavioral: Motivational interviewing plus exposure and response prevention (MI plus EX/RP)
  • Active Comparator: 2
    Participants will receive exposure and response prevention only
    Intervention: Behavioral: Exposure and response prevention (EX/RP)
Farris SG, McLean CP, Van Meter PE, Simpson HB, Foa EB. Treatment response, symptom remission, and wellness in obsessive-compulsive disorder. J Clin Psychiatry. 2013 Jul;74(7):685-90. doi: 10.4088/JCP.12m07789.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
30
March 2010
March 2010   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Primary diagnosis of OCD as defined by DSM-IV
  • Obsessions and/or compulsions must have been present for at least one year
  • At pre-treatment, a minimum on Y-BOCS on items 1-10 of 16
  • If on psychiatric medication, patient has been on stable SRI dose for a minimum of 12 weeks (and four weeks for concomitant OCD meds,e.g., benzos and antipsychotics) and plans to remain on a stable dose for the duration of the EX/RP+MI treatment.
  • Able to provide informed consent
  • No prior adequate EX/RP treatment (defined as at least 8 exposure sessions that include response prevention instructions and between sessions assignments in a 2 month period)
  • Based on hx, subject is unlikely to require a change in med during the course of EX/RP/EX/RP+MI treatment

Exclusion Criteria:

  • Any additional medical or psychiatric conditions that could make participation in the study medically inadvisable
  • Currently receiving psychotherapy at another clinic
Both
18 Years to 70 Years
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00316316
#5124, R34MH071570, DAHBR 96-BHA
No
New York State Psychiatric Institute
New York State Psychiatric Institute
National Institute of Mental Health (NIMH)
Principal Investigator: Helen Blair Simpson, MD, PhD New York State Psychiatric Institute
New York State Psychiatric Institute
March 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP