Study of Sildenafil in Patient With Heart Failure.

This study has been completed.
Sponsor:
Information provided by:
Massachusetts General Hospital
ClinicalTrials.gov Identifier:
NCT00309816
First received: March 30, 2006
Last updated: NA
Last verified: March 2006
History: No changes posted

March 30, 2006
March 30, 2006
December 2001
Not Provided
Patients will have exercise capacity measured by an exercise stress test before and after one dose of sildenafil.
Same as current
No Changes Posted
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Study of Sildenafil in Patient With Heart Failure.
Measurement of the Effect of Sildenafil Citrate (Viagra) on the Hemodynamics of Exercise Tolerance in Advanced Congestive Heart Failure.

The purpose of this study is to determine if sildenafil (Viagra) improves exercise tolerance.

Patients will undergo an exercise stress test. One dose of Sildenafil will then be given, followed by a one hour rest period. A repeat exercise stress test will then be repeated.

Interventional
Phase 3
Allocation: Non-Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Congestive Heart Failure
Drug: sildenafil
Not Provided
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
40
February 2006
Not Provided

Inclusion Criteria:

Age 18 - 75 Ejection fraction <35% Heart failure limited by fatigue and shortness of breath -

Exclusion Criteria:

Inability to exercise. Patients with shortness of breath while resting. Patient requiring intravenous medication. Patients taking the following medications: nitroglycerine pill/patch/paste, isordil and Imdur

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Both
18 Years to 75 Years
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00309816
2001-p-001039
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Massachusetts General Hospital
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Principal Investigator: Marc J Semigran, MD Massachusetts General Hospital
Massachusetts General Hospital
March 2006

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP