fMRI in Posttraumatic Stress Disorder (PTSD) During Working Memory Updating (METRAPI)

This study has been completed.
Sponsor:
Information provided by:
University Hospital, Tours
ClinicalTrials.gov Identifier:
NCT00288314
First received: February 3, 2006
Last updated: March 16, 2010
Last verified: March 2010

February 3, 2006
March 16, 2010
January 2007
May 2008   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT00288314 on ClinicalTrials.gov Archive Site
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fMRI in Posttraumatic Stress Disorder (PTSD) During Working Memory Updating
Working Memory Updating in Posttraumatic Stress Disorder (PTSD): Study of Neural Correlates Using fMRI

Neuropsychological studies investigating trauma-exposed and posttraumatic stress disorder (PTSD) subjects have generally underlined the significantly poorer performance of tasks that require attention, concentration, and verbal memory, and difficulty in regulating memories surrounding the traumatic event. A previous study (El Hage et al. Cognitive Neuropsychiatry, 2006) revealed that the trauma-exposed subjects scored higher on anxiety/depression scales, and lower on processing speed tests. Moreover, the study showed significant impairment in working memory partially mediated by speed processing, but not by anxiety or depression. These results suggest that processing speed makes a major contribution to trauma-related working memory decline, and needs to be investigated in further studies.The aim of the present study is to explore correlation between hippocampus volume, frontal dysfunction and cognitive slowing in trauma-exposed subjects, while examining brain activation during performance of working memory tasks using functional magnetic resonance.

Working memory performance will be assessed using the "3-back test", and processing speed evaluated with "words comparison test". The study will be conducted on 2 years. The study should include 18 right-handed females victims of sexual abuse and suffering from PTSD, and 18 controls right-handed females without any history of abuse ad not suffering from PTSD. Brain activation will be measured during performance of working memory tasks (3-back test) and processing speed test using functional magnetic resonance.

Observational
Observational Model: Case Control
Time Perspective: Cross-Sectional
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Probability Sample

PTSD related to sexual abuse vs controls, in right-handed females.

  • Post-Traumatic Stress Disorders
  • Anxiety
  • Amnesia, Dissociative
Procedure: Magnetic Resonance Imaging, Functional
Structural and functional MRI
  • PTSD
    Intervention: Procedure: Magnetic Resonance Imaging, Functional
  • CONTROLS
    Intervention: Procedure: Magnetic Resonance Imaging, Functional
El-Hage W, Gaillard P, Isingrini M, Belzung C. Trauma-related deficits in working memory. Cognit Neuropsychiatry. 2006 Jan;11(1):33-46.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
34
May 2008
May 2008   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Right-handed women
  • Victim of sexual abuse
  • Suffering from PTSD

Exclusion Criteria:

  • Epilepsy
  • Claustrophobia
  • MRI contre-indication
  • Addictive disorders
  • Sightless
  • Detection of a brain injury at the MRI
Female
18 Years to 40 Years
Yes
Contact information is only displayed when the study is recruiting subjects
France
 
NCT00288314
PHRR04-WEH/METRAPI
Yes
PHRR, CHRU TOURS
University Hospital, Tours
Not Provided
Principal Investigator: Wissam EL HAGE, MD, PhD UNIVERSITY HOSPITAL OF TOURS
University Hospital, Tours
March 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP