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Effect of Exercise Intervention on Various Physiologic Factors That Change With Increasing Age

This study has been completed.
Sponsor:
Information provided by:
Mayo Clinic
ClinicalTrials.gov Identifier:
NCT00283673
First received: January 27, 2006
Last updated: June 3, 2011
Last verified: June 2011

January 27, 2006
June 3, 2011
September 1995
January 1998   (final data collection date for primary outcome measure)
Insulin sensitivity
Same as current
Complete list of historical versions of study NCT00283673 on ClinicalTrials.gov Archive Site
  • Muscle Mitochondrial Protein Synthesis
  • mRNA of mitochondrial genes
  • mRNA of genes involved in mitochondrial biogenesis
Same as current
Not Provided
Not Provided
 
Effect of Exercise Intervention on Various Physiologic Factors That Change With Increasing Age
Impact of Aerobic Exercise Training on Age Related Changes in Insulin Sensitivity and Muscle Oxidative Capacity

This study randomized healthy sedentary people age 20-80 years to 16 weeks of supervised exercise versus no exercise. Several end points were evaluated after 16 weeks including insulin sensitivity and muscle physiology.

Healthy subjects performing < 30 min exercise twice per week were studied prior to randomization and after of sixteen weeks exercise. They were randomized to sixteen weeks of supervised exercise performed on a stationary bike vs. placebo exercise (a series of flexibility exercises performed at home). Intensity, duration and frequency of exercise were gradually increased to four sessions per week lasting forty minutes each and achieving 80% target heart rate. Participants were weighed perioidically and counseled appropriately when weight changed by > 2 %. Insulin sensitivity and muscle mitochondrial protein synthesis were studied.

Interventional
Not Provided
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind
Aging
Behavioral: Exercise
Not Provided
Short KR, Vittone JL, Bigelow ML, Proctor DN, Rizza RA, Coenen-Schimke JM, Nair KS. Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity. Diabetes. 2003 Aug;52(8):1888-96.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
102
January 1998
January 1998   (final data collection date for primary outcome measure)

Healthy subjects performing < 30 min exercise twice per week. Age 20-90 years. Willing to be randomized to exercise versus no exercise. Willing to be studied in General Clinical Research Center with studies including Muscle Biopsy.

Both
20 Years to 90 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00283673
350-95, RO1AG09531
Not Provided
Not Provided
Mayo Clinic
Not Provided
Principal Investigator: K. Sreekumaran Nair, M.D. Mayo Clinic
Mayo Clinic
June 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP