Genetics of Rolandic Epilepsy

The recruitment status of this study is unknown because the information has not been verified recently.
Verified August 2011 by King's College London.
Recruitment status was  Recruiting
Sponsor:
Collaborator:
Information provided by:
King's College London
ClinicalTrials.gov Identifier:
NCT00282854
First received: January 26, 2006
Last updated: December 5, 2011
Last verified: August 2011

January 26, 2006
December 5, 2011
January 2005
December 2013   (final data collection date for primary outcome measure)
Not Provided
Not Provided
Complete list of historical versions of study NCT00282854 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Genetics of Rolandic Epilepsy
Genetics of Rolandic Epilepsy

The purpose of this study is to find the genes that cause Rolandic epilepsy and its related traits.

Rolandic epilepsy (RE) is the most common type of childhood epilepsy—affecting more than 50,000 children in the United States—and has a complex genetic inheritance. The seizure prognosis is relatively benign, however, many children with RE also have problems with speech and language, reading, and motor coordination. Symptoms of the disorder overlap with more severe types of epilepsy.

The purpose of this study is to find the genes that influence RE and its related traits. Identifying genetic causes for the variants would improve diagnosis and allow for early intervention.

Researchers will enroll 1000 children with RE and 3000 controls for participation in the study. The scientists will request medical histories and (salivary) DNA samples from the participants. Participation can be completed by mail and telephone.

Results from this study should provide important information regarding diagnosis and prognosis of RE, may be useful in clinical management, and, eventually, may lead to a cure for this and other forms of epilepsy.

Observational
Observational Model: Case Control
Time Perspective: Cross-Sectional
Not Provided
Retention:   Samples With DNA
Description:

whole blood

Non-Probability Sample

Community Sample

Epilepsy
Not Provided
  • Group I: Cases
    Children with rolandic epilepsy
  • Group II: Controls
    Individuals group matched to cases for ethnicity, sex and area of residence but lacking a primary brain disorder.
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
1000
December 2013
December 2013   (final data collection date for primary outcome measure)

Inclusion:

  • typical history of focal seizures
  • EEG centrotemporal sharp waves
  • age of onset 3-12 years
  • no previous epilepsy type (febrile seizures OK)
  • normal development
  • normal neurological examination
  • normal MRI/CT (if done)

Exclusion:

  • only history of secondary generalized seizures
  • atypical history/semiology
  • history and EEG inconsistent
  • abnormal EEG background
  • very early (<3yrs) or late (>12yrs) onset
  • global neurodevelopmental deficit
  • deviant neurodevelopment
  • structural imaging abnormality
Both
3 Years and older
No
Contact: Deb Pal, MD, PhD 212 342 1237 dkp28@columbia.edu
United States
 
NCT00282854
4727, R01NS047530
No
Deb K Pal MD PHD, Columbia University
King's College London
National Institute of Neurological Disorders and Stroke (NINDS)
Principal Investigator: Deb K. Pal, MD, PhD Associate Research Scientist, Mailman School of Public Health, Columbia University Medical Center
King's College London
August 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP