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Role of Epicardial Adipose Tissue in Coronary Artery Disease

The recruitment status of this study is unknown because the information has not been verified recently.
Verified January 2006 by McMaster University.
Recruitment status was  Recruiting
Sponsor:
Collaborator:
Heart and Stroke Foundation of Canada
Information provided by:
McMaster University
ClinicalTrials.gov Identifier:
NCT00279227
First received: January 17, 2006
Last updated: August 9, 2006
Last verified: January 2006

January 17, 2006
August 9, 2006
January 2006
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Complete list of historical versions of study NCT00279227 on ClinicalTrials.gov Archive Site
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Role of Epicardial Adipose Tissue in Coronary Artery Disease
Role of Epicardial Adipose Tissue in Coronary Artery Disease

We sight to evaluate whether patients with coronary artery disease (CAD) have more epicardial fat than patients without CAD, which would suggest that epicardial fat may be more than an “innocent bystander” and be actively involved in the disease process. Its role as a modulator of vascular response and myocardial function could potentially lead to new areas of cardiac research. We also sight to evaluate whether epicardial fat from patients with CAD releases more adipokines than subcutaneous fat from these patients which could prompt studies into the differential regulation of adipokine secretion in this tissue. Thus for e.g., the use of thiazolidinediones (glitazones), statins, ARBs or other compounds that can specifically modulate adipokine secretion could be explored to determine their benefit in ameliorating the effects attributable to increased epicardial fat.

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Observational
Observational Model: Defined Population
Time Perspective: Cross-Sectional
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  • Coronary Artery Disease
  • Obesity
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
50
December 2006
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Inclusion Criteria:

  • All patients elegible for elective cardiac surgery are elegible
  • Ability to provide written informed consent in accordance with GCP guidelines and local legislations.
  • > 18 years of age

Exclusion Criteria:

  • Control patients will not have clinical signs of CAD and will show normal coronary arteries on angiography.
  • Any medical, social or geographic condition, which, in the opinion of the investigator would not allow safe or reliable completion of the protocol.
Both
18 Years and older
No
Contact: Suzana Damjanovic, MLT, CCRA 905-527-4322 ext 44710 suzana@cardio.on.ca
Canada
 
NCT00279227
EPICARD Study
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Hamilton Health Sciences Corporation
Heart and Stroke Foundation of Canada
Principal Investigator: Arya M Sharma, MD, FRCPC McMaster University
McMaster University
January 2006

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP