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Activation and Recruitment of GIL During Hp Infection

The recruitment status of this study is unknown because the information has not been verified recently.
Verified December 2005 by National Taiwan University Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT00275886
First received: January 11, 2006
Last updated: NA
Last verified: December 2005
History: No changes posted

January 11, 2006
January 11, 2006
January 2006
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No Changes Posted
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Activation and Recruitment of GIL During Hp Infection
Activation and Recruitment of Gastric Infiltrating Lymphocytes During H. Pylori Infection

Helicobacter pylori is a major human pathogen that infects over half of the world population. Infection initiates a series of changes in the gastric mucosa, beginning with gastritis and leading in some patients to peptic ulcer disease, mucosa-associated lymphomas, and gastric adenocarcinoma. It is believed that host factors, in particular, the T cell-mediated immune responses may play an important role in the pathogenesis of diseases induced by H. pylori infection. Recent results revealed that there were higher IFN-γ secreting cells in gastric infiltrating T cells isolated from H. pylori infected patients than in uninfected patients, suggesting that the TH1 response and degree of IFN-γ production is associated with disease severity. Meanwhile, recent studies have shown that apoptosis of the gastric epithelium is increased during infection and this response is associated with an expansion of gastric T-helper type 1 (Th1) cells. In this project, we are trying to further investigate role of host T cell mediated immune response in pathogenesis of Helicobacter infection by characterization of the expression of chemokine receptors on gastric infiltrating lymphocytes. We are going to investigate the mechanisms involving in chemokine/chemokine receptor interaction in recruitment of gastric infiltrating lymphocytes and pathogenesis of gastric mucosa damage in Helicobacter infection. This study will be helpful for understanding the mechanisms of activation and recruitment of gastric-infiltrating lymphocytes during gastric inflammation.

Specific Aim #1: Characterization of the gastric infiltrating T cells from H. pylori gastritis patients A. Patients H. pylori infected gastritis and asymptomatic patients are selected from National Taiwan University hospital. The gastric biopsy specimen are taken from endoscopic biopsy in routine health check up or panendoscopic examination for the despeptic patients. HP negative gastritis patients will also be studied for negative control.

B. Immunohistochemical identification of T cells and expression of chemokine receptors.

Specific Aim #2 . Isolation and characterization of chemokines and chemokine receptors of the infiltrating lymphocytes in H. pylori-associated gastritis tissue

A. Isolation of gastric infiltrating lymphocyte B. Identification of the expression of chemokine receptor in gastric infiltrating lymphocytes by flow cytometry C. Detection of expression of chemokines in gastric tissues

Observational
Observational Model: Case Control
Primary Purpose: Screening
Time Perspective: Cross-Sectional
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  • Helicobacter Gastritis
  • Dyspepsia
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
30
December 2008
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Inclusion Criteria:

  • patients receiveing endoscopy examination due to dyspepsia

Exclusion Criteria:

  • nil
Both
20 Years to 60 Years
No
Contact: Ping-Ning Hsu, MD, PhD 886-2-23123456 ext 8635 phsu@ha.mc.ntu.edu.tw
Taiwan
 
NCT00275886
9461701221
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National Taiwan University Hospital
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Principal Investigator: Ping-Ning Hsu, MD, PhD Department of Immunology
National Taiwan University Hospital
December 2005

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP