Resynchronization of Left Ventricular Contraction After Reimplantation of Anomalous Left Coronary Artery

This study has been terminated.
(sufficient data collected for analysis)
Sponsor:
Information provided by:
Children's Healthcare of Atlanta
ClinicalTrials.gov Identifier:
NCT00268112
First received: December 20, 2005
Last updated: March 14, 2012
Last verified: December 2006

December 20, 2005
March 14, 2012
January 2004
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Complete list of historical versions of study NCT00268112 on ClinicalTrials.gov Archive Site
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Resynchronization of Left Ventricular Contraction After Reimplantation of Anomalous Left Coronary Artery
Resynchronization of Left Ventricular Contraction After Re-implantation of Anomalous Left Coronary Artery From the Pulmonary Artery (ALCAPA) Evaluated by Tissue Doppler Imaging

Spontaneous resynchronization of dyskinetic segments of the left ventricle occurs after coronary bypass surgery in adults and has been shown in some children. It is, however, unknown what degree of dyskinesis is likely to be reversible in infants with ischemia from anomalous coronary arteries and what criteria would indicate that a resynchronization strategy of biventricular pacing might be needed.

These questions need data from quantitative serial tissue Doppler observations of patients from pre-operative to late post-operative follow-up.

We have previously studied, at Children's Healthcare of Atlanta, Egleston Hospital, 2 patients with ALCAPA and one other patient is currently enrolled in a prospective study after recent surgery, also at Children's Healthcare of Atlanta. We propose to study these 3 patients with this rare defect concurrently with their routine echocardiographic evaluations. Data will then be taken off-line for analysis.

Standard deviations of times to peak contraction velocity will be assessed for twelve cardiac segments. These will be reevaluated at follow up intervals after surgery on previously obtained echocardiograms. Those subjects in whom improvement of cardiac function, Left Ventricular Ejection Fraction (LVEF) and mitral regurgitation is seen will be compared to those in whom no improvement occurs.

Observational
Time Perspective: Retrospective
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Non-Probability Sample

Cardiac pediatric patients

Congenital Disorders
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Terminated
3
December 2006
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Inclusion Criteria:

  • Re-implantation of an anomalous left coronary artery from the pulmonary artery

Exclusion Criteria:

  • those patients who do not meet inclusion criteria
Both
up to 21 Years
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00268112
05-203
No
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Children's Healthcare of Atlanta
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Principal Investigator: Derek A. Fyfe, MD, PhD Sibley Heart Center Cardiology at Children's Healthcare of Atlanta
Children's Healthcare of Atlanta
December 2006

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP