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Genetic Epidemiological Study of Lung Cancer in Taiwan and Clinical Applications

The recruitment status of this study is unknown because the information has not been verified recently.
Verified July 2011 by National Health Research Institutes, Taiwan.
Recruitment status was  Active, not recruiting
Sponsor:
Collaborators:
National Taiwan University Hospital
Taipei Veterans General Hospital, Taiwan
Chang Gung Memorial Hospital
Taichung Veterans General Hospital
National Cheng-Kung University Hospital
Kaohsiung Medical University
Information provided by:
National Health Research Institutes, Taiwan
ClinicalTrials.gov Identifier:
NCT00260871
First received: December 1, 2005
Last updated: July 27, 2011
Last verified: July 2011

December 1, 2005
July 27, 2011
May 2002
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Complete list of historical versions of study NCT00260871 on ClinicalTrials.gov Archive Site
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Genetic Epidemiological Study of Lung Cancer in Taiwan and Clinical Applications
Genetic Epidemiological Study of Lung Cancer in Taiwan and Clinical Applications-focusing on Female Lung Adenocarcinoma (GEFLAC)

Lung adenocarcinoma in Chinese females is hypothesized to be determined by both genetic and environmental factors. In this grant proposal, we propose to map the loci of susceptibility genes of female lung adenocarcinoma based on multiplex families recruited in Taiwan. We focus on a unique pathological type of a unique population in order to reduce heterogeneity of the genetic background. Compared with western women, female Chinese population has a high prevalence of lung adenocarcinoma. Our reasoning is that if we focus on a specific sub-type, which has a familial basis, we will increase the probability of identifying genes associated with female lung adenocarcinoma. The primary goal of this study is to identify the genetic and environmental determinants of female lung adenocarcinoma, and study the relationship between gene polymorphisms and clinical manifestation profiling of lung cancer.

This research proposal intends to integrate epidemiologists, biostatisticians, clinicians, molecular biologists/geneticists to identify susceptible genes for lung cancer, especially for female lung adenocarcinoma, and to study the relationship between gene polymorphisms and clinical outcomes of lung cancer patients. Our objective is to find gene markers for developing useful screening tools for the high risk group in order to prevent or early detect lung cancer, especially female lung adenocarcinoma.

The specific aims of this subproject include:

  1. Establish and maintain the research network that will recruit and follow up the subjects and families for the GEFLAC study; keeping control of the progress of the study.
  2. Coordinate all the subprojects such as integrating genotyping data with clinical data and environment data.
  3. Continue to employ the candidate gene approach to examine the contribution of specific genes to the lung cancer.
  4. Generate genotyping data for candidate genes in the exploring stage and prioritize SNPs of candidate genes for large scale studies.
  5. Identify susceptible genes/candidate genes to develop multiplex PCR for screening.
Observational
Observational Model: Case Control
Time Perspective: Prospective
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Non-Probability Sample

The program project intend to identify susceptible genes for lung cancer, especially for female lung adenocarcinoma.

Lung Cancer
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
1500
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Inclusion Criteria:

  • lung adenocarcinoma

Exclusion Criteria:

-

Both
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No
Contact information is only displayed when the study is recruiting subjects
Taiwan
 
NCT00260871
94LCP005, 1.DOH-94-TD-G-111-025, 2.DOH-94-TD-G-111-027
Yes
Dr. Chao Agnes Hsiung, Institute of Population Health Sciences, National Health Research Instiutes, Taiwan
National Health Research Institutes, Taiwan
  • National Taiwan University Hospital
  • Taipei Veterans General Hospital, Taiwan
  • Chang Gung Memorial Hospital
  • Taichung Veterans General Hospital
  • National Cheng-Kung University Hospital
  • Kaohsiung Medical University
Study Director: Chao Hsiung, PhD NHRI
National Health Research Institutes, Taiwan
July 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP