Food Rheology and Feeding in Lean and Obese Humans

This study has been completed.
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Richard Mattes, Purdue University
ClinicalTrials.gov Identifier:
NCT00260130
First received: November 29, 2005
Last updated: May 28, 2013
Last verified: May 2013

November 29, 2005
May 28, 2013
February 2005
December 2007   (final data collection date for primary outcome measure)
satiation and satiety on liquid verses solid foods with concurrent measurements of appetite, dietary intake, energy expenditure and body weight/composition. [ Time Frame: 8 weeks ] [ Designated as safety issue: No ]
satiation and satiety on liquid verses solid foods with concurrent measurements of appetite, dietary intake, energy expenditure and body weight/composition.
Complete list of historical versions of study NCT00260130 on ClinicalTrials.gov Archive Site
cephalic phase testing at week 8 [ Time Frame: 30 minutes ] [ Designated as safety issue: No ]
cephalic phase testing at week 8
Not Provided
Not Provided
 
Food Rheology and Feeding in Lean and Obese Humans
Study 1: Viscosity Study Study 2: Meal Timing Study Study 3:Chronic Fluid and Solid Food Intake in Lean and Overweight Individuals

The 2010 National Health Objectives call for a reduction in the prevalence of obesity. The marked recent increase in overweight and obesity prevalence implicates behavioral factors in the etiology of the epidemic. The present proposal hypothesizes the trend is attributal, in part, to increasing consumption of energy-yeilding beverages since they are a significant and increasing source of dietarty energy and they elicit weaker appetitive and dietary responses than solid foods.

Three human studies are propsed to more fully characterized attributes of liquids and solids that may account for the differential appetitive responses they elicit, potential contributory mechanisms as well as the dietary implications of their consumption. Study 1 will contrast the acute effects of fluid and solid foods varying in macronutrient content on satiation, satiety and feeding. Study 2 will determine if the pattern of fluid and solid ingestion influences satiety and feeding by monitoring appetitive and dietary responses to energy and macronutrient matched fluid and solid loads ingested as meal components or between meal snacks. To better assess the clinical implications ofdiets incorpprating liquid or solid supplements. Study 3 will entail chronic ingestion of matched energy yeilding fluid or solid loads with concurrent measurement of appetite, dietary intake, energy expenditureand body weight/composition.

Interventional
Not Provided
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Open Label
  • Obesity
  • Overweight
  • Diabetes
  • Other: food in fluid form
    dietary intake of fluid forms of vegetables
  • Other: food in solid form
    dietary intake of solid forms of vegetables
  • Active Comparator: 1
    Consuming fruit and vegetable juice
    Intervention: Other: food in fluid form
  • Active Comparator: 2
    Consuming whole fruits and vegetables
    Intervention: Other: food in solid form
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
34
July 2009
December 2007   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • BMI 18-23 or 27-35
  • weight stable
  • constant habitual activity pattern
  • low fruit/vegetable consumer
  • non-restrained eater

Exclusion Criteria:

  • diabetic
  • taking medication known to influence appetite
Both
18 Years to 40 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00260130
DK63185 (completed), R01DK063185, Study 1: 503001275, Study 2: 508002908, Study 3: 505002589
Not Provided
Richard Mattes, Purdue University
Purdue University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Principal Investigator: Richard D Mattes, MPH, PhD, RD Purdue University
Purdue University
May 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP