Laparoscopy in Children: Does it Decrease the Metabolic, Endocrine and Inflammatory Stress Response to Surgery

This study has been completed.
Sponsor:
Information provided by:
Institute of Child Health
ClinicalTrials.gov Identifier:
NCT00231543
First received: October 3, 2005
Last updated: October 11, 2006
Last verified: October 2005

October 3, 2005
October 11, 2006
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resting energy expenditure
Same as current
Complete list of historical versions of study NCT00231543 on ClinicalTrials.gov Archive Site
  • whole body protein turnover
  • indices of inflammatory response
  • pro and anti inflammatory cytokines
  • free radical production
  • post operative pain
Same as current
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Laparoscopy in Children: Does it Decrease the Metabolic, Endocrine and Inflammatory Stress Response to Surgery
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The aim of this trial was to characterise the intra and post operative metabolic, endocrine and inflammatory response to laparoscopic fundoplication in children. We are testing the hypothesis that laparoscopic fundoplication is associated with a lack of hypermetabolism and catabolism and blunting of the endocrine/inflammatory stress response

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Interventional
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Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Gastro-Oesophageal Reflux
  • Procedure: Laparoscopic fundoplication
  • Procedure: open Nissen fundoplication
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
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Inclusion Criteria:

  • infants and children with gastro-oesophageal reflux

Exclusion Criteria:

  • septic shock, multi-organ dysfunction syndrome, cardiac, renal or congenital metabolic abnormalities
Both
1 Month to 16 Years
No
Contact information is only displayed when the study is recruiting subjects
United Kingdom
 
NCT00231543
99SG92
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Institute of Child Health
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Principal Investigator: Agostino Pierro, Prof Institute of Child Health
Institute of Child Health
October 2005

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP