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Cytokine Regulation of Periradicular Pain in Humans

This study has been completed.
Sponsor:
Collaborators:
National Institutes of Health (NIH)
National Institute of Dental and Craniofacial Research (NIDCR)
Information provided by (Responsible Party):
The University of Texas Health Science Center at San Antonio
ClinicalTrials.gov Identifier:
NCT00223470
First received: September 13, 2005
Last updated: March 7, 2012
Last verified: March 2012
History of Changes

September 13, 2005
March 7, 2012
October 2002
June 2008   (final data collection date for primary outcome measure)
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Not Provided
Complete list of historical versions of study NCT00223470 on ClinicalTrials.gov Archive Site
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Cytokine Regulation of Periradicular Pain in Humans
Cytokine Regulation of Periradicular Pain in Humans

This clinical trial evaluates the role of cytokines in patients needing root canal treatment with diagnosis of necrotic pulp and chronic apical periodontitis

This study evaluates whether periradicular exudate concentrations of cytokines differ in patients experiencing pain and mechanical allodynia due to pulpal necrosis with an acute exacerbation of a chronic apical periodontitis, as compared to patients with pulpal necrosis with chronic apical periodontitis, but no pain or mechanical allodynia
Observational
Observational Model: Case Control
Time Perspective: Prospective
Not Provided
Retention:   Samples Without DNA
Description:

Sterile paper points are placed in the canal for 30 seconds
Non-Probability Sample

Patients presenting to the Endodontics department with an indication for root canal treatment
Chronic Apical Periodontitis of Pulpal Origin
Not Provided
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
9
June 2008
June 2008   (final data collection date for primary outcome measure)

Inclusion Criteria:

  1. Patient must be at least 16 years of age.
  2. Clinical indication for Non-Surgical Root Canal Therapy (NSRCT).
  3. 1st or 2nd maxillary or mandibular molar
  4. Diagnosis must be Chronic Apical Periodontitis (CAP) with or without symptoms.
  5. Intact, mature apices.
  6. ASA I or II

Exclusion Criteria:

  1. Failure to meet any of the above
  2. Previous NSRCT
  3. Previous pulpotomy or pulpectomy
  4. Suppurative apical periodontitis
  5. Patients taking medications which can affect their pain rating or medications which effect their immune system ( such as glucocorticoids)
Both
16 Years to 60 Years
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00223470
012-1904-455, K23DE014864-01A1S1
No
The University of Texas Health Science Center at San Antonio
The University of Texas Health Science Center at San Antonio
  • National Institutes of Health (NIH)
  • National Institute of Dental and Craniofacial Research (NIDCR)
Principal Investigator: Asma A Khan, BDS, PhD University of Texas Health Science Center at San Antonio
The University of Texas Health Science Center at San Antonio
March 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP