Optimizing Cardiac Resynchronization

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
University of Wisconsin, Madison
ClinicalTrials.gov Identifier:
NCT00205192
First received: September 12, 2005
Last updated: August 28, 2012
Last verified: August 2012

September 12, 2005
August 28, 2012
June 2004
December 2011   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT00205192 on ClinicalTrials.gov Archive Site
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Optimizing Cardiac Resynchronization
Optimizing Cardiac Resynchronization

Cardiac resynchronization therapy shows great promise as a method to improve ventricular function in heart failure due to dilated cardiomyopathy. It is applied to patients with class III and IV symptomatic heart failure on optimal therapy. Typical entry criteria in the trials testing resynchronization have used the electrocardiogram and a prolonged electrocardiogram (ECG) QRS interval as criteria for dyssynchrony. This is recognized to be quite limited as a tool for identifying patients. Several new echocardiographic methods for identifying dyssynchrony have been proposed. The purpose of this study is to systematically examine these multiple echocardiographic measurement techniques in three conditions:

  1. in the patient's native rhythm simulated by changing the pacing system to atrial pacing only;
  2. in conventional dual chamber pacing (DDD mode); and
  3. during biventricular pacing. All patients entered into this study will already have had a biventricular pacemaker placed.
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Observational
Observational Model: Case Control
Time Perspective: Prospective
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Non-Probability Sample

Patients who have previously had a resynchronization pacemaker system placed at the University of Wisconsin Hospital or at the Middleton Veterans Hospital are potentially eligible for this study.

Heart Failure
Procedure: Cardiac resynchronization pacing
various pacemaker modes used over 1 hour
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
100
December 2011
December 2011   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • All patients who have previously had a resynchronization pacemaker system placed at the University of Wisconsin Hospital or at the Middleton Veterans Hospital are potentially eligible for this study.
  • The study is only open to patients as enumerated above, and also patients who have good imaging windows.
Both
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No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00205192
H-2004-0335
No
University of Wisconsin, Madison
University of Wisconsin, Madison
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Principal Investigator: Peter S Rahko, MD University of Wisconsin, Madison
University of Wisconsin, Madison
August 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP