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Acute, Affective, Organic Disorders.

This study has been completed.
Sponsor:
Collaborators:
St. Olavs Hospital
Dr. Dedichens Institute for Psychiatric Research, Oslo, Norway.
GlaxoSmithKline
Information provided by:
Norwegian University of Science and Technology
ClinicalTrials.gov Identifier:
NCT00201474
First received: September 16, 2005
Last updated: June 7, 2010
Last verified: June 2010

September 16, 2005
June 7, 2010
October 1998
October 2004   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT00201474 on ClinicalTrials.gov Archive Site
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Acute, Affective, Organic Disorders.
Signs of Organic Brain Dysfunction in Psychiatric Patients With Fluctuating Psychiatric Symptoms Including Brief Depressions Compared to Patients With a Major Depressive Episode.

The purpose of the study is to investigate whether patients with brief depressive periods together with other fluctuating psychiatric symptoms, have this condition due to epilepsy or an other organic brain disorder.

A limited number of patients admitted to psychiatric acute wards or Psychiatric Intensive Care Units are admitted with a fluctuating array of psychiatric symptoms including brief depressive episodes. These patients do not fit into the present diagnostic systems due to short duration of affective symptoms and the fluctuating arrays of other symptoms. Case histories indicate that these patients have psychiatric conditions due to epilepsy or organic brain dysfunctions.

In the study acutely admitted patients filling criteria for two recent DSM-4 axis 1 diagnoses (one is a brief depressive period) during the last two weeks are compared to age- and sex-matched patients acutely admitted with a major depressive disorder. The patients are rated with a number of rating scales at admittance, day 5, after two weeks and three months. EEG and QEEG are taken three times the first week. MRI, drug screening and blood screening of medication-concentrations are taken.

Observational
Observational Model: Case Control
Time Perspective: Prospective
Not Provided
Retention:   Samples Without DNA
Description:

Ordinary laboratory tests, medication, substances.

Probability Sample

Study and control groups both from a psychiatric acute ward. The patients are acutely admitted suffering from different types of depressive symptoms.

  • Acute Psychiatry
  • Depressive Disorders
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Vaaler AE, Morken G, Linaker OM, Sand T, Kvistad KA, Bråthen G. Symptoms of epilepsy and organic brain dysfunctions in patients with acute, brief depression combined with other fluctuating psychiatric symptoms: a controlled study from an acute psychiatric department. BMC Psychiatry. 2009 Sep 30;9:63.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
32
June 2010
October 2004   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Acutely admitted psychiatric patients who have at different times the last 2 weeks filled criteria for at least two new DSM-4 Axis 1 psychiatric diagnoses. One of them has to be a depressive episode (MADRS>20)

Exclusion Criteria:

  • Patients not speaking Norwegian or English.
  • Patients not willing to participate.
  • Patients with dementia or mental retardation to an extensive degree.
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
Norway
 
NCT00201474
AEV-98
No
Prof Olav Linaker, St Olavs University Hospital, Division Psychiatry, Norwegian University of Science and Technology
Norwegian University of Science and Technology
  • St. Olavs Hospital
  • Dr. Dedichens Institute for Psychiatric Research, Oslo, Norway.
  • GlaxoSmithKline
Study Chair: Olav M Linaker, Professor Norwegian University of Science and Technology
Norwegian University of Science and Technology
June 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP