Switching to Duloxetine From Other Antidepressants

This study has been completed.
Sponsor:
Information provided by:
Eli Lilly and Company
ClinicalTrials.gov Identifier:
NCT00191932
First received: September 12, 2005
Last updated: July 21, 2006
Last verified: July 2006

September 12, 2005
July 21, 2006
August 2004
Not Provided
To test the hypothesis that the efficacy associated with direct switch from SSRI to duloxetine is non-inferior to start-taper switch
Same as current
Complete list of historical versions of study NCT00191932 on ClinicalTrials.gov Archive Site
To compare the efficacy, health outcomes, safety and tolerability associated with the above two switching methods, as measured by HAMD17, CGI-S, PGI-I, SF-36, spontaneously reported adverse events , vital signs and other measures.
Same as current
Not Provided
Not Provided
 
Switching to Duloxetine From Other Antidepressants
Switching to Duloxetine From Other Antidepressants: A Regional Multicentre Trial Comparing Two Switching Techniques

A multicentre, randomised, open label study of out-patients with major depression who have failed to respond adequately to antidepressant treatment for their current episode of depression. The study compares outcomes associated with two methods of switching from current antidepressant to duloxetine

Not Provided
Interventional
Phase 4
Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Major Depressive Disorder
Drug: Duloxetine
Not Provided
Perahia DG, Quail D, Desaiah D, Corruble E, Fava M. Switching to duloxetine from selective serotonin reuptake inhibitor antidepressants: a multicenter trial comparing 2 switching techniques. J Clin Psychiatry. 2008 Jan;69(1):95-105.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
360
March 2006
Not Provided

Inclusion Criteria:

  • Male and female outpatients of at least 18 years of age, who meet criteria for Major Depressive Disorder (MDD)
  • Currently non- or only partially-responsive to an SSRI antidepressant after at least 5 weeks of treatment

Exclusion Criteria include:

  • Current primary Axis I disorder other than MDD
  • Previous diagnosis of bipolar disorder, schizophrenia, or other psychotic disorders
  • Patients judged to be at serious suicidal risk.
  • Serious medical illness
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
France,   Ireland,   Spain,   United Kingdom
 
NCT00191932
8604, F1J-MC-HMDG
Not Provided
Not Provided
Eli Lilly and Company
Not Provided
Study Director: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST) Eli Lilly and Company
Eli Lilly and Company
July 2006

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP