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Early Diagnosis of Lung Cancer and Mesothelioma in Prior Asbestos Workers

The recruitment status of this study is unknown because the information has not been verified recently.
Verified January 2012 by University Health Network, Toronto.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
University Health Network, Toronto
ClinicalTrials.gov Identifier:
NCT00188890
First received: September 12, 2005
Last updated: January 19, 2012
Last verified: January 2012

September 12, 2005
January 19, 2012
March 2005
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Complete list of historical versions of study NCT00188890 on ClinicalTrials.gov Archive Site
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Early Diagnosis of Lung Cancer and Mesothelioma in Prior Asbestos Workers
Early Diagnosis of Mesothelioma and Lung Cancer Following Asbestos Exposure Using Low-dose Computed Tomography

Occupational exposure to asbestos is known increase the risk of developing cancer of the lungs (bronchogenic carcinoma) or of the pleura (mesothelioma). Symptoms are subtle and non-specific, diagnosis is often late and the prognosis consequently is dismal. Currently there is no accepted non-invasive tool for the early diagnosis of mesothelioma or lung cancer in asbestos-exposed subjects. In the last decade, low-dose computed tomography (LDCT) has been successfully developed and validated for the early diagnosis of lung cancer in high-risk smokers. Malignant mesothelioma might, in an early stage, resemble a benign pleural plaque, which is a common finding after asbestos exposure. We target to develop low-dose CT as a tool to serially image the pleural plaques, quantify their individual and overall volume, compute the growth rate with time, and, as such, identify the presence of mesothelioma early, before symptoms occur.

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Observational
Observational Model: Case Control
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Non-Probability Sample

prior exposure to asbestos and or documented pleural plaques

  • Lung Cancer
  • Mesothelioma
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1
prior exposure to asbestos
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
1000
March 2013
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Inclusion Criteria:

prior asbestos exposure at least 20 years ago and/or documented pleural plaques (chest x-ray evidence)

Resident of Ontario, Canada

Exclusion Criteria:

prior cancer (except non-melanotic skin cancer)

Both
30 Years to 85 Years
Yes
Contact: Demetris Patsios, MD Tel: (416) 603-5800 ext 2583 demetris.patsios@uhn.on.ca
Contact: Brenda O'Sullivan 416-340-4800 ext 5686 Brenda.O'Sullivan@uhn.on.ca
Canada
 
NCT00188890
Asbestos Screening Study
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Demetris Patsios, MD, UHN
University Health Network, Toronto
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Principal Investigator: Demetris Patsios, MD University Health Network, Toronto
Principal Investigator: Marc de Perrot, MD University Health Network, Toronto
University Health Network, Toronto
January 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP