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Dynamic Profiles of Cytokine/Chemokine in Severe Acute Respiratory Syndrome

This study has been completed.
Sponsor:
Information provided by:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT00173459
First received: September 12, 2005
Last updated: NA
Last verified: July 2004
History: No changes posted

September 12, 2005
September 12, 2005
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Dynamic Profiles of Cytokine/Chemokine in Severe Acute Respiratory Syndrome
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Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by a novel coronavirus (SARS-CoV). The major clinical features of SARS include fever, dyspnea, lymphopenia, and a rapid progression of pulmonary infiltrates on chest radiologic images. The SARS-related deaths have resulted mainly from pulmonary complications, including progressive respiratory failure due to alveolar damage and acute respiratory distress syndrome (ARDS). Pathological changes in SARS suggest that SARS sequelae such as infiltration of PMN in lung tissue, multiple organ dysfunction and ARDS have been associated with cytokines and chemokine dysregulation. Some patients still manifested lung injury at a time when the viral load was falling also supports the immune nature of the lung damage. We therefore undertook an analysis of dynamic production of cytokine/chemokines in SARS patients with an initial normal chest radiograph in order to improve understanding of disease pathogenesis and improve patient management.

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Observational
Observational Model: Case Control
Time Perspective: Longitudinal
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SARS
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
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Inclusion Criteria:

  • SARS group: Patients with SARS

Exclusion Criteria:

  • Hospital acquired pneumonia
Both
20 Years and older
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Contact information is only displayed when the study is recruiting subjects
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NCT00173459
9461700671
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National Taiwan University Hospital
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Study Chair: Jung-Yien Chien, MD NTUH
National Taiwan University Hospital
July 2004

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP