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The Difference in Presentation Level of Variant Receptors in Female Breast Tissue in Macromastia and Micromastia

The recruitment status of this study is unknown because the information has not been verified recently.
Verified June 2005 by National Taiwan University Hospital.
Recruitment status was  Not yet recruiting
Sponsor:
Information provided by:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT00173251
First received: September 12, 2005
Last updated: NA
Last verified: June 2005
History: No changes posted

September 12, 2005
September 12, 2005
January 2006
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difference in receptor expression level
Same as current
No Changes Posted
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The Difference in Presentation Level of Variant Receptors in Female Breast Tissue in Macromastia and Micromastia
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There are more and more macromastic women in Taiwan, which may due to the high cholesterol foods. Patients with macromastia not only suffered from physical problems but also psychological discomforts.

Large breasts cause neck and back pain, irritating grooves, cut in the skin of the shoulders by the pressure of brassiere straps, breast pain, and maceration and dermatoses in the inframammary region. From a psychological point of view, excessively large breasts can be troublesome focus of embarrassment for the teenager as well as the woman in her senior years. Unilateral hypertrophy with asymmetry heightens embarrassment. Thus, patients seek to reduce the size of their breasts.

In the human female, variant receptors were detected in epithelial cells in normal breast tissue, benign breast lesions, breast carcinoma tissue, and breast cancer cell lines2-11. The cause of the difference in breast development status is still unclear. Abnormalities at the tissue receptor level may be important in the pathophysiology of macromastia. This study aimed to make clear the difference in variant receptor levels between breast hypertrophy patients and macromastia ones by examining the receptor levels in breast tissue. Then, we could explore the possible etiology of mammary hypertrophy and macromastia.

Interventional
Phase 1
Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Educational/Counseling/Training
Aging
Procedure: obtain surgical specimen for analysis
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Not yet recruiting
60
August 2006
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Inclusion Criteria:

  • patients receiving reduction mammoplasty

Exclusion Criteria:

-

Both
20 Years to 80 Years
Yes
Contact: Hao-Chih Tai, M.D. 886-2-23123456 ext 5109 phoebe@ha.mc.ntu.edu.tw
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NCT00173251
9461700605
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National Taiwan University Hospital
Not Provided
Principal Investigator: Hao-Chih Tai, M.D. National Taiwan University Hospital
National Taiwan University Hospital
June 2005

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP