Angiotensin Converting Enzyme Gene Polymorphism in Children With Idiopathic Nephrotic Syndrome

This study has been completed.
Sponsor:
Information provided by:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT00172276
First received: September 12, 2005
Last updated: September 14, 2005
Last verified: June 2005

September 12, 2005
September 14, 2005
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Complete list of historical versions of study NCT00172276 on ClinicalTrials.gov Archive Site
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Angiotensin Converting Enzyme Gene Polymorphism in Children With Idiopathic Nephrotic Syndrome
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Aims This study was conducted to examine the association between the ACE insertion/deletion (I/D) genotype distribution in children with idiopathic nephrotic syndrome and the response to steroid therapy.

Patients and Methods The patients with idiopathic nephrotic syndrome were divided into 2 groups according to their clinical response to steroid: SS group including infrequent and frequent relapsers and non-SS group including steroid resistant (SR) and steroid dependent (SD) patients. Children without previous renal diseases and negative proteinuria were enrolled as control group in genetic study. The genotypes for ACE gene I/D polymorphism including DD, ID and II were analyzed by the newly developed automatic denaturing high performance liquid chromatography system (DHPLC).

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Observational
Observational Model: Case Control
Time Perspective: Cross-Sectional
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Nephrotic Syndrome
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
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Inclusion Criteria:

  • Total 59 children diagnosed as nephrotic syndrome at the age of 1 to 10 year-old were recruited in this study. These children with nephrotic syndrome were under follow-up at the Pediatric Nephrology Clinic in National Taiwan University Hospital. In addition, children without previous renal diseases and negative proteinuria were enrolled as control group in genetic study.
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1 Year to 10 Years
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Contact information is only displayed when the study is recruiting subjects
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NCT00172276
9261701241
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National Taiwan University Hospital
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Principal Investigator: Yong-Kwei Tsau, MD National Taiwan University Hospital
National Taiwan University Hospital
June 2005

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP