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GR Defect in Peripheral Blood Mononuclear Cells in COPD

This study has been completed.
Sponsor:
Collaborator:
AstraZeneca
Information provided by:
Imperial College London
ClinicalTrials.gov Identifier:
NCT00159237
First received: September 8, 2005
Last updated: August 12, 2008
Last verified: August 2008

September 8, 2005
August 12, 2008
February 2005
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Complete list of historical versions of study NCT00159237 on ClinicalTrials.gov Archive Site
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GR Defect in Peripheral Blood Mononuclear Cells in COPD
GR Defect in Peripheral Blood Mononuclear Cells in COPD

T.to investigate a possible mechanism of the glucocorticosteroid receptors (GR) defect in patients with severe COPD by studying the effect of dexamethasone (Dex) on GR- binding, interleukin production (IL-6/IL-8) and MKP-1 expression in peripheral blood mononuclear cells blood (PBMC)

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Observational
Time Perspective: Prospective
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Chronic Obstructive Pulmonary Disease
Procedure: blood test
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
30
December 2008
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Inclusion Criteria:

  • Patients with severe (stage III, Gold) to very severe (stage IV, GOLD) COPD or subjects who are healthy smokers or subjects who are non-smokers
  • Written informed consent

Exclusion Criteria:

  • Current upper respiratory tract infections
  • Any significant disease or disorder (e.g. cardiovascular, pulmonary (other than asthma), gastrointestinal, liver, renal, neurological, musculoskeletal, endocrine, metabolic, malignant, psychiatric, major physical impairment) which, in the opinion of the investigator, may either put the subject at risk because of participation in the study, or may influence the results of the study, or the subjects ability to participate in the study
  • Subjects not considered capable, as judged by the investigator, of following instructions of the study, e.g. because of a history of alcohol or drug abuse or any other reason
Both
35 Years to 85 Years
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Contact information is only displayed when the study is recruiting subjects
United Kingdom
 
NCT00159237
D5899N00007
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Imperial College London
AstraZeneca
Principal Investigator: Sergei A Kharitonov, MD PhD Imperial College London
Imperial College London
August 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP