Analysis of Genetic Factors Related to Predisposition and Prognosis of Hematological Malignancies in Israel

The recruitment status of this study is unknown because the information has not been verified recently.
Verified June 2011 by Hadassah Medical Organization.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Hadassah Medical Organization
ClinicalTrials.gov Identifier:
NCT00159003
First received: September 8, 2005
Last updated: June 22, 2011
Last verified: June 2011

September 8, 2005
June 22, 2011
January 1998
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Complete list of historical versions of study NCT00159003 on ClinicalTrials.gov Archive Site
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Analysis of Genetic Factors Related to Predisposition and Prognosis of Hematological Malignancies in Israel
Molecular Analysis of Genetic Elements Which May Influence Predisposition and Prognosis of Hematological Malignancies in Different Ethnic Groups in Israel

There are naturally occuring variations in the genetic makeup of all of us. Some of these variations may contribute to a change in susceptibility toward different diseases or change the prognosis.

We are studying these genetic variations in patients with leukemia. The genes we are studying are those which influence detoxification of drugs and toxins.

We have prepared DNA on patients with leukemia (AML, CML and CLL) and we are studying the influence of polymorphisms in drug metabolism and disposition genes on predisposition and prognosis of these types of leukemia. The genes we are studying include: MDR1, CYP3A4, NQO1, NAT1/2, GST, hOCT. We plan to study other genes that may be contributory.

Study includes comparing the frequency of polymorphisms in these genes with the frequency in the general population and the study of DNA biding proteins which bind at the sites of these polymorphisms.

Observational
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:

DNA only

Non-Probability Sample

Patients admitted to Hadassah Hospital with AML or CLL.

  • Acute Myeloid Leukemia
  • Chronic Lymphocytic Leukemia
  • Chronic Myelogenous Leukemia
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Chanock S. Genetic variation and hematology: single-nucleotide polymorphisms, haplotypes, and complex disease. Semin Hematol. 2003 Oct;40(4):321-8. Review.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
300
April 2012
Not Provided

Inclusion Criteria:

  • diagnosis of acute myeloid leukemia or chronic lymphocytic leukemia

Exclusion Criteria:

  • under 18 years of age
Both
18 Years and older
No
Contact: Deborah G Rund, MD 972-2-6778712 rund@cc.huji.ac.il
Israel
 
NCT00159003
132910-HMO-CTIL
No
Deborah Rund, Hadassah Medical Organization
Hadassah Medical Organization
Not Provided
Principal Investigator: Deborah G Rund, MD Hadassah Medical Organization
Hadassah Medical Organization
June 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP