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Developing Criteria for Cortical Resections

This study is currently recruiting participants.
Verified January 2013 by University of Chicago
Sponsor:
Information provided by (Responsible Party):
Wim van Drongelen, University of Chicago
ClinicalTrials.gov Identifier:
NCT00152659
First received: September 7, 2005
Last updated: January 8, 2013
Last verified: January 2013
History of Changes

September 7, 2005
January 8, 2013
September 1998
December 2030   (final data collection date for primary outcome measure)
measure electrical activity in tissue sample [ Time Frame: at tissue aremoval time ] [ Designated as safety issue: No ]
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Complete list of historical versions of study NCT00152659 on ClinicalTrials.gov Archive Site
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Developing Criteria for Cortical Resections
Developing Functional and Structural Criteria for Cortical Resections

The purpose of this study is to study how disease processes like tumors or epilepsy spread in the brain.

The purpose of this study is to study how disease processes like tumors or epilepsy spread in the brain. During surgery small pieces of abnormal (unusual) brain tissue may be removed. We analyze these specimens using more advanced microscopic and electrophysiologic techniques than are usually applied to such tissue specimens. In addition, some tissues can be maintained in laboratory conditions to allow analysis over the longer term. No extra brain tissue is taken to perform these studies. The tissue analysis is performed by the research team and are compared to the routine (normal) electrical recordings that are taken during this type of brain surgery. Currently there are no instructions telling a doctor how much brain tissue should be cut out to prevent the spread of tumors or epilepsy. We are hoping that the results of this study help us to better know how much brain tissue needs to be removed to prevent the spread of tumors or epilepsy.
Observational
Time Perspective: Retrospective
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Non-Probability Sample

Surgical candidates with epilepsy or brain tumor(s)
  • Epilepsy
  • Tumor
Procedure: Tissue sample (procedure/screening)
Tissue sampling
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  • Ramirez J-M, Koch H, Pena F, Drongelen W van, Tryba AK, Parkis MA, Loweth JA, Hecox KE, Kohrman MH, Frim DM, Chico MS, Marcuccilli CJ (2003) - In vitro electrophysiological differences between least and most abnormal tissue obtained from pediatric patients with intractable epilepsy. Epilepsia 44, Suppl 9: 245-246
  • Marcuccilli CJ, Koch H, Pena F, Drongelen W van, Tryba AK, Parkis MA, Hecox KE, Kohrman MH, Frim DM, OConnor SE, Chico MS, Ramirez J-M (2003) - Rational pharmacotherapy: relationship between in vitro electrophysiology and clinical measures. Epilepsia 44, Suppl 9: 244-245
  • Drongelen W van, Doren EL, Koch H, Marcuccilli CJ, Ramirez J-M, Elsen FP (2005) - Characterization of the persistent sodium current in neocortical networks of mice and humans. Abstract Washington DC: Society for Neuroscience

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
1000
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December 2030   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Surgical candidates with epilepsy or brain tumor(s)
Both
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No
Contact: Wim van Drongelen, Ph.D. 773-834-9049 wvandron@peds.bsd.uchicago.edu
Contact: Jan-Marino Ramirez, Ph.D. 773-702-3713 jramire@uchicago.edu
United States
 
NCT00152659
9538
No
Wim van Drongelen, University of Chicago
University of Chicago
Not Provided
Principal Investigator: Wim van Drongelen, Ph.D. University of Chicago
University of Chicago
January 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP