Activity of the Auditory Cortex During Speech Perception and Speech Production in Stuttering

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2006 by University Hospital Muenster.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
University Hospital Muenster
ClinicalTrials.gov Identifier:
NCT00148161
First received: September 6, 2005
Last updated: April 26, 2007
Last verified: September 2006

September 6, 2005
April 26, 2007
November 2004
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Complete list of historical versions of study NCT00148161 on ClinicalTrials.gov Archive Site
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Activity of the Auditory Cortex During Speech Perception and Speech Production in Stuttering
Evoked and Induced Auditory Cortical Activity During Speech Perception and Speech Production in Stuttering

The goal of the study is to examine the cortical activity during speech perception and speech production in idiopathic stutterers compared to fluent speakers. Therefore, the noninvasive method of magnetoencephalography (MEG) is used. A better understanding for the complexity of speech perception and its pathology should be developed.

Fundamental properties of stuttering are repetitions, prolongations, and blocks. In most cases stuttering emerges between 2 and 5 years of age. The auditory feedback should become less important during development, as soon as information about mispronounced words does not occur anymore. During speech development this control function should be adopted by other systems. In stutterers the dominance of the acoustic control should remain.

Brain imaging studies with positron emission tomography (PET) or magnetic resonance imaging (MRI) show defects in the network of motor system, in the lateralization of speech areas, and functions of the auditory cortex. Magnetoencephalographic studies describe a similar variety as cause of stuttering. There may be defects in the auditory feedback, a modification of the lateralization of speech areas, or an alteration of co-action of motor planning and auditory system.

The benefit of magnetoencephalography is a very good temporal resolution in the range of milliseconds combined with good spatial resolution. Therefore, it is well suited to examine the dynamics of cortical processing during stuttering. In this study evoked components of the auditory systems related to complex sounds, vocals, consonant-vocal combinations, and single words are analyzed. Differences of these components in the auditory cortices of stutterers and fluent speakers are hypothesized as well in temporal structure as in localization and lateralization.

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Observational
Observational Model: Defined Population
Time Perspective: Cross-Sectional
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Stuttering
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
20
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Inclusion Criteria:

  • Subjects with idiopathic stuttering (for the group of stutterers)
  • Fluently speaking subjects (for the control group)
  • Right handed
  • Normal hearing

Exclusion Criteria:

  • Neurological diseases
  • Psychiatric diseases
  • Medication with neurological effective drugs
  • Implants with magnetic impact
Male
18 Years and older
Yes
Contact: Antoinette G Dinnesen, Prof. Dr. +49(0)251 83 ext 56859 a.g.dinnesen@uni-muenster.de
Contact: Arne Knief, Dr. +49(0)251 83 ext 56886 knief@uni-muenster.de
Germany
 
NCT00148161
phonpaed001
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University Hospital Muenster
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Study Director: Antoinette G Dinnesen, Prof. Dr. Department of Phoniatrics and Pediatric Audiology, University Hospital Münster
Principal Investigator: Arne Knief, Dr. Department of Phoniatrics and Pediatric Audiology, University Hospital Münster
University Hospital Muenster
September 2006

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP