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Gefitinib in Treating Patients Who Are Undergoing Surgery and/or Radiation Therapy for Locally Advanced or Recurrent Squamous Cell Skin Cancer

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by (Responsible Party):
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT00126555
First received: August 2, 2005
Last updated: February 13, 2013
Last verified: February 2013

August 2, 2005
February 13, 2013
March 2005
February 2013   (final data collection date for primary outcome measure)
  • Early progression rate [ Time Frame: Up to 2 courses of induction therapy ] [ Designated as safety issue: No ]
  • Feasibility rate [ Time Frame: Up to 7 weeks ] [ Designated as safety issue: No ]
    Determined by the surgical healing time (resectable patients) and of concomitant gefitinib by treatment interruption during radiotherapy.
  • Toxicity as assessed by the National Cancer Institute (NCI) Common Toxicity Criteria [ Time Frame: Up to 5 years ] [ Designated as safety issue: Yes ]
    Severity and timing of toxicities will be evaluated. Occurrences of late (post-radiation) toxicities that are radiation-related will be carefull monitored.
Not Provided
Complete list of historical versions of study NCT00126555 on ClinicalTrials.gov Archive Site
  • Clinical response according to RECIST [ Time Frame: Up to 5 years ] [ Designated as safety issue: No ]
  • Frequency and timing of local and distant failures [ Time Frame: From study entry to first documented local recurrence or last patient contact, assessed up to 5 years ] [ Designated as safety issue: No ]
  • Change in EGFR and phospho-Akt expression [ Time Frame: From baseline to up to 30 days ] [ Designated as safety issue: No ]
Not Provided
Not Provided
Not Provided
 
Gefitinib in Treating Patients Who Are Undergoing Surgery and/or Radiation Therapy for Locally Advanced or Recurrent Squamous Cell Skin Cancer
A Phase II Study of ZD1839 and Radiation in Patients With Squamous Cell Carcinoma of the Skin

The goal of this clinical research study is to learn if giving Iressa (Gefitinib or ZD1839) with surgery and/or radiation will help to control squamous cell carcinoma of the skin. The safety of this treatment will also be studied

PRIMARY OBJECTIVES:

I. Early progression rate (progression during ZD1839 induction). II. Feasibility of induction ZD1839 (for all patients) and concomitant ZD1839 with radiotherapy (for unresectable patients).

III. Toxicities of induction ZD1839 (for all patients) and concomitant ZD1839 with radiotherapy (for unresectable patients).

SECONDARY OBJECTIVES:

I. Response: clinical responses to induction therapy. II. Failures: frequency and timing of local and distant failures. III. Biomarkers: biomarker levels in tumor and normal tissue.

TERTIARY OBJECTIVES:

I. For progressive disease responders, patients will be followed for locoregional and distant metastases data.

II. Feasibility of maintenance ZD1839. III. Toxicities of maintenance ZD1839.

OUTLINE: Patients are assigned to 1 of 2 groups.

STRATUM I (initially resectable tumor): Patients undergo radiotherapy once daily (QD) 5 days a week for approximately 6-7 weeks. Patients also receive gefitinib orally (PO) QD for up to 12 months

STRATUM II (initially unresectable tumor): Patients undergo radiotherapy QD 5 days a week for approximately 6-7 weeks. Patients also receive concurrent gefitinib PO QD for 6-7 weeks. Patients then undergo surgery. After surgery, patients receive gefitinib PO QD for up to 12 months.

After completion of study treatment, patients are followed up for up to 5 years.

Interventional
Phase 2
Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
  • Recurrent Skin Cancer
  • Squamous Cell Carcinoma of the Skin
  • Drug: gefitinib
    Given PO
    Other Names:
    • Iressa
    • ZD 1839
  • Radiation: radiation therapy
    Undergo radiotherapy
    Other Names:
    • irradiation
    • radiotherapy
    • therapy, radiation
  • Procedure: conventional surgery
    Undergo surgery
    Other Name: surgery, conventional
  • Other: laboratory biomarker analysis
    Correlative studies
  • Experimental: Stratum I (gefitinib, radiotherapy, surgery)
    Patients undergo radiotherapy QD 5 days a week for approximately 6-7 weeks. Patients also receive gefitinib PO QD for up to 12 months.
    Interventions:
    • Drug: gefitinib
    • Radiation: radiation therapy
    • Other: laboratory biomarker analysis
  • Experimental: Stratum II (gefitinib, radiotherapy, surgery)
    Patients undergo radiotherapy QD 5 days a week for approximately 6-7 weeks. Patients also receive concurrent gefitinib PO QD for 6-7 weeks. Patients then undergo surgery. After surgery, patients receive gefitinib PO QD for up to 12 months.
    Interventions:
    • Drug: gefitinib
    • Radiation: radiation therapy
    • Procedure: conventional surgery
    • Other: laboratory biomarker analysis
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
63
Not Provided
February 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Within 12 weeks (+/- 2 weeks) prior to study entry, patients must have histologically or cytologically confirmed squamous cell carcinoma (SCC) of skin that is either locally advanced or recurrent with measurable disease; if the biopsy was collected outside of MDACC, the MDACC Pathology Department must assess and confirm the SCC diagnosis
  • Patients may have previous surgical intervention with residual or recurrent disease
  • ECOG performance status =< 2 (Karnofsky >= 60%)
  • Leukocytes >= 3,000/mm^3
  • Absolute neutrophil count >= 1,500/mm^3
  • Platelets >= 100,000/mm*3
  • Total bilirubin within normal institutional limits
  • AST (SGOT) and ALT (SGPT) =< 2.5 x institutional upper limit of normal
  • Creatinine within normal institutional limits OR; creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal
  • Tumors must be at least 2 cms in size or have histological or cytological verification of muscle, bone, lymph node metastasis, or perineural involvement, as measured by the treating physician(s) or National PI
  • Negative serum pregnancy test for women of child-bearing potential (performed within 14 days, +/- 1 day, prior to start of treatment); women of child-bearing potential and men must agree to use adequate contraception prior to study entry and for the duration of study participation; should a woman become pregnant or suspect she is pregnant while participating in the study, she should inform her treating physician(s) immediately
  • Ability to understand and the willingness to sign a written Informed Consent Document (ICD); in the event that non-English speaking participants are eligible for this study, a short form (if applicable) or an ICD in their language, will be utilized and completed in accordance with the MDACC "Policy For Consenting Non-English Speaking Participants"

Exclusion Criteria:

  • Patients who have previous radiotherapy to the proposed site of skin cancer
  • Patients with active cancers other than skin
  • Patients currently receiving any other investigational agents at time of study enrollment; patients may have received investigational agents in the past; no washout time period is required
  • Patients with a history of brain metastases must be excluded from this clinical study because of their poor prognosis and because they often develop progressive neurological dysfunction that would confound the evaluation of neurological and other adverse events
  • History of allergic reactions attributed to compounds of similar chemical or biologic composition to ZD1839
  • Age less than 18 years
  • Presence of uncontrolled intercurrent illness (co-morbid conditions) that would limit compliance with study requirements including , but not limited to, ongoing or active infection requiring parenteral antibiotics at time of study registration, symptomatic congestive heart failure (NYHA class II or greater), unstable angina pectoris or cardiac arrhythmia requiring maintenance medication
  • Pregnant women are excluded from this study because ZD1839 is a signal transduction inhibitor agent with the potential for teratogenic or abortifacient effects; there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with ZD1839, breastfeeding should be discontinued if the mother is treated with ZD1839
  • Patients with known immune deficiency are at an increased risk when treated with marrow-suppressive therapy, HIV-positive patients receiving combination anti-retroviral therapy are excluded due to the possible pharmacokinetic interactions with ZD1839; appropriate studies will be undertaken in patients receiving combination anti-retroviral therapy when indicated
  • CYP3A4 inducing agents; patients receiving the following CYP3A4 inducing agents will be excluded; these include: carbamazepine, ethosuximide, griseofulvin, modafinil, nafcillin, oxcarbazepine, Phenobarbital, phenylbutazone, phenytoin, rifampin, rifabutin, St. John's Wort, and sulfinpyrazone
  • Patients with distant metastatic disease as determined by diagnostic imaging (i.e., chest x-rays) and/or hematologic assessments (i.e., liver enzymes)
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00126555
NCI-2012-02893, 2004-0204
Not Provided
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Not Provided
Principal Investigator: Randal Weber M.D. Anderson Cancer Center
National Cancer Institute (NCI)
February 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP