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Childhood Autism Risks From Genetics and the Environment (The CHARGE Study)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified March 2005 by National Institute of Environmental Health Sciences (NIEHS).
Recruitment status was  Recruiting
Sponsor:
Collaborators:
University of California, Davis
University of California, Los Angeles
Information provided by:
National Institute of Environmental Health Sciences (NIEHS)
ClinicalTrials.gov Identifier:
NCT00106652
First received: March 28, 2005
Last updated: June 23, 2005
Last verified: March 2005

March 28, 2005
June 23, 2005
September 2001
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Complete list of historical versions of study NCT00106652 on ClinicalTrials.gov Archive Site
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Childhood Autism Risks From Genetics and the Environment (The CHARGE Study)
Environmental Factors in the Etiology of Autism

The purpose of this study is to understand how genes, environment, and the interplay between the two, influences the development of autism and other neurodevelopmental disorders.

The causes and contributing factors for autism are poorly understood. Evidence suggests that incidence is increasing, but diagnostic changes and improvements may be playing a role. Both genetic and environmental factors appear to play a role. Autopsy studies demonstrate structural changes in the brain and clinical investigations reveal neurophysiologic differences in information processing in autistic versus normal children. Members of our team recently demonstrated altered levels of certain neuropeptides at birth in children who later developed autism.

This case-control study is the first large-scale epidemiologic investigation of underlying causes for autism and triggers of regression. This study capitalizes on the strengths of the case-control design, which is well suited to examine a broad array of factors for rare conditions that are thought to be multifactorial. Comparisons will be made with both general population controls and mentally retarded children.

The aims are to assess the influence of exogenous exposures, the role of susceptibility factors, and the interplay between these two in the etiology of autism and its phenotypic variation. Chemicals with known or suspected neurodevelopmental toxicity, such as PCB’s, certain pesticides, and metals, are being investigated. This study pursues several hypotheses that have recently gained attention, including the combined measles, mumps, rubella vaccine and mercury present in vaccines given during infancy and early childhood. Additionally, biochemical susceptibility is examined through characterization of metabolic, immunologic, and neuronal gene expression profiles and genetic polymorphisms.

Observational
Observational Model: Case Control
Primary Purpose: Screening
Time Perspective: Cross-Sectional
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  • Autism
  • Developmental Disabilities
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
2000
September 2006
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Inclusion Criteria:

  • Children between 2 and 5 years old
  • Born in California
  • Parents must speak either English or Spanish
  • Children must be living with at least one biologic parent

Exclusion Criteria:

  • Children not meeting eligibility criteria listed above
  • Children not residing in selected geographical areas (please contact for more information about specific study locations)
Both
24 Months to 60 Months
Yes
Contact: Melissa Rose, B.Sci. (530) 754-8157 mbrose@ucdavis.edu
United States
 
NCT00106652
11269-CP-001, 200210574-4
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National Institute of Environmental Health Sciences (NIEHS)
  • University of California, Davis
  • University of California, Los Angeles
Principal Investigator: Isaac N. Pessah, Ph.D. University of California, Davis
Study Director: Irva Hertz-Picciotto, Ph.D. University of California, Davis
National Institute of Environmental Health Sciences (NIEHS)
March 2005

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP