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Metabolic Syndrome, Inflammation, and Risk of Cognitive Decline

This study has been completed.
Study NCT00099567.   Last updated on October 31, 2005.   Information provided by National Institute on Aging (NIA)

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Descriptive Information Fields
Brief Title  Metabolic Syndrome, Inflammation, and Risk of Cognitive Decline
Official Title  Metabolic Syndrome, Inflammation, and Risk of Cognitive Decline
Brief Summary

The purpose of this study is to determine if the metabolic syndrome is a risk factor for cognitive decline and if this association is modified by inflammation.

Detailed Description

The metabolic syndrome is a clustering of several commonly occurring disorders that include abdominal obesity, high triglycerides, low HDL cholesterol, high blood pressure, and insulin resistance. This study was conducted to determine if, as hypothesized, the presence of the metabolic syndrome is associated with more cognitive decline and greater risk of developing cognitive impairment, and whether this risk is affected by the level of inflammatory markers in the blood.

This 5-year prospective observational study was conducted from 1997 to 2002 at community clinics in two locations. A total of 2632 black and white participants, aged 70 to 79 years, were recruited from the 3075 participants in the Health, Aging and Body Composition (ABC) study conducted during the same period. Participants were screened for presence of metabolic syndrome, cognitive status, inflammatory markers, and a clinic examination was administered, when the study began and at the year 3 and 5 follow-up visits.

Study Phase
Study Type  Observational
Study Design  Natural History, Longitudinal, Random Sample, Prospective Study
Primary Outcome Measure 
Secondary Outcome Measure 
Condition  Cognitive Decline
Intervention 
MEDLINE PMIDs 15536110,   12847160,   11031212
Links
Recruitment Information Fields
Recruitment Status  Completed
Enrollment  2632
Start Date  January 1997
Completion Date December 2002
Eligibility Criteria 

Inclusion Criteria:

  • Aged 70 to 79
  • White or Black
  • Community-dwelling in Memphis, TN or Pittsburgh, PA vicinity
  • Well-functioning (no difficulty in walking a quarter of a mile or going up 10 steps without resting)

Exclusion Criteria:

  • Any difficulty with activities of daily living
  • Clinical dementia
  • Inability to communicate with interviewer
  • Intention of moving out of vicinity in the next year
  • Active treatment for cancer in the previous 3 years
  • Participation in a trial involving a lifestyle intervention
Gender Both
Ages 70 Years to 79 Years
Accepts Healthy Volunteers Yes
Contacts ††
Location Countries  United States
Administrative Information Fields
NCT ID  NCT00099567
Organization ID IA0066
Secondary IDs †† 1N01AG062106, 1R01AG021918
Study Sponsor  National Institute on Aging (NIA)
Collaborators †† Paul Beeson Faculty Scholars Program
University of California, San Francisco
Investigators 
Principal Investigator:     Kristine Yaffe, MD     University of California, San Francisco    
Information Provided By National Institute on Aging (NIA)
Verification Date December 2004
First Received Date  December 16, 2004
Last Updated Date October 31, 2005

 †    Required WHO trial registration data element.
††   WHO trial registration data element that is required only if it exists.




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