|
|
![]() |
![]() |
![]() |
![]() |
|
![]() |
|
![]() |
|
![]() |
![]() |
![]() |
|
![]() |
||||||||||||||||||||||||||||||||||||
| Descriptive Information Fields | |
| Brief Title † | Rifaximin Versus Placebo in the Prevention of Travelers' Diarrhea |
| Official Title † | A Randomized, Double-Blind, Single Center, Comparative Dose Ranging Study of Rifaximin Vs. Placebo in the Prevention of Travelers' Diarrhea Due to Enteropathogenic Bacteria |
| Brief Summary | The purpose of this study is to evaluate the effectiveness of poorly absorbed rifaximin in the prevention of travelers' diarrhea among U.S. college students in Mexico for five weeks. |
| Detailed Description | This is an investigator-initiated proposal wherein 220 male and female subjects >17 years of age from industrialized regions were randomized to receive a poorly absorbed antibiotic, rifaximin, in one of three doses at mealtime (when they are exposed to diarrhea-causing bacteria), 200 mg once a day, 200 mg twice a day or 200 mg three times a day versus a placebo starting on arrival (within the first 72 hours) to Mexico and continuing for two weeks with diaries of symptoms recorded for three weeks. Adverse events in the subjects were followed for five weeks. If mild diarrhea (1 or 2 unformed stools/24 hours plus an enteric symptom) or diarrheal illness (>2 unformed stools/24 hours plus an enteric symptom) developed, subjects provided a stool sample to determine cause of illness. Forty subjects provided stool samples after 7 days and 14 days treatment to see if their intestinal bacterial flora had developed resistance to rifaximin and to see the level of drug achieved. Stool samples from these forty subjects were studied for enteric pathogens to look for asymptomatic infection during the period of prophylaxis. The stool samples collected were initially processed in our enteric laboratories in Guadalajara, Mexico. Specialized tests such as studies of toxigenicity for enterotoxigenic E. coli and enteroadherence for enteroaggregative E. coli were done in Houston. |
| Study Phase | Phase II |
| Study Type † | Interventional |
| Study Design † | Prevention, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study |
| Primary Outcome Measure † | Occurrence of diarrhea, defined as passage of >2 unformed stools/24 hr plus one or more signs or symptoms of enteric infection |
| Secondary Outcome Measure † | Occurrence of mild diarrhea (1 or 2 unformed stools/24 hr plus a sign or symptom) Treatment failure (not well in five days) Occurrence of moderate to severe abdominal pain/cramps or intestinal gas related symptoms |
| Condition † | Diarrhea |
| Intervention † | Drug: rifaximin |
| MEDLINE PMIDs | 15897530, 11692292, 8502272 |
| Links | |
| Recruitment Information Fields | |
| Recruitment Status † | Completed |
| Enrollment † | 220 |
| Start Date † | June 2003 |
| Completion Date | September 2003 |
| Eligibility Criteria † | Inclusion Criteria:
Exclusion Criteria:
|
| Gender | Both |
| Ages | 18 Years and older |
| Accepts Healthy Volunteers | Yes |
| Contacts †† | |
| Location Countries † | Mexico |
| Administrative Information Fields | |
| NCT ID † | NCT00098384 |
| Organization ID | PR 03 |
| Secondary IDs †† | |
| Study Sponsor † | DuPont, Hurbert L., MD |
| Collaborators †† | Salix Pharmaceuticals The University of Texas Health Science Center, Houston |
| Investigators † | |
| Information Provided By | DuPont, Hurbert L., MD |
| Verification Date | December 2004 |
| First Received Date † | December 7, 2004 |
| Last Updated Date | May 8, 2006 |