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Parkinson's Research: The Organized Genetics Initiative (PROGENI)

This study has been completed.
Sponsor:
Collaborators:
The Parkinson Study Group
Children's Hospital Medical Center, Cincinnati
National Institute of Neurological Disorders and Stroke (NINDS)
Information provided by:
Indiana University
ClinicalTrials.gov Identifier:
NCT00086073
First received: June 22, 2004
Last updated: February 15, 2011
Last verified: November 2010
History of Changes

June 22, 2004
February 15, 2011
August 1998
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Complete list of historical versions of study NCT00086073 on ClinicalTrials.gov Archive Site
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Parkinson's Research: The Organized Genetics Initiative
Parkinson's Disease Collaborative Study of Genetic Linkage

The purpose of this trial is to study genetic and other risk factors that may be important in the development of Parkinson's disease.

The The Parkinson's Research: The Organized Genetics Initiative, also known as PROGENI, is a multi-center study involving 2000 people throughout North America who are affected, or possibly affected, with Parkinson's disease (PD). The goal of the initiative is to study the genetic and other risk factors which may be important in the development of PD.

In order to better understand the genetic factors leading to PD, researchers will study families having 2 or more members diagnosed with PD. Using DNA samples from each participant, researchers hope to identify genes that may cause a person to be at higher risk for developing PD.

Each participant in the study will be asked to complete a family history questionnaire, providing information about the history of PD in the family. Participants also will be asked to discuss the symptoms they have experienced and their responses to PD medications. This information will be used by study personnel to determine further eligibility for the study. Those eligible for further participation will be asked to undergo a study visit at the site closest to their residence, during which they will be asked to complete questionnaires regarding PD symptoms, medical history, places of residence, occupations, mood, mental status, and activity level. A blood sample will be drawn for DNA extraction. The study visit will take about 2 hours.
Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:

blood sample
Non-Probability Sample

families having 2 or more members diagnosed with PD
Parkinson Disease
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
1800
January 2011
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Inclusion Criteria:

  • To be eligible to participate in this study participants must be diagnosed with or have symptoms of PD. In addition, they must also have a family history of PD in other relatives.

Exclusion Criteria:

  • Subjects cannot have participated in any other genetic research project for Parkinson's disease.
Both
Not Provided
No
Contact information is only displayed when the study is recruiting subjects
United States,   Canada,   Puerto Rico
 
NCT00086073
9703-09, R01NS37167
No
Tatiana Foroud, Ph.D, Principal Investigator, Indiana University
Indiana University School of Medicine
  • The Parkinson Study Group
  • Children's Hospital Medical Center, Cincinnati
  • National Institute of Neurological Disorders and Stroke (NINDS)
Principal Investigator: Tatiana Foroud, Ph.D. Indiana University
Indiana University
November 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP