Genetics of Fibromyalgia

The recruitment status of this study is unknown because the information has not been verified recently.
Verified March 2009 by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by:
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
ClinicalTrials.gov Identifier:
NCT00071162
First received: October 14, 2003
Last updated: March 31, 2009
Last verified: March 2009

October 14, 2003
March 31, 2009
September 1999
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Complete list of historical versions of study NCT00071162 on ClinicalTrials.gov Archive Site
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Genetics of Fibromyalgia
Fibromyalgia Family Study Registry

The Fibromyalgia Family Study identifies and collects blood samples from families with two or more members affected with Fibromyalgia Syndrome (FMS). The primary goal of the study is to identify genes that predispose people to FMS and/or symptoms related to FMS; identifying these genes may lead to a better understanding of the disease and more effective treatments.

FMS predominantly affects women and is characterized by chronic widespread musculoskeletal pain, fatigue, sleep disturbance, and multiple tender points on physical examination. The pathophysiological mechanisms underlying FMS are not clearly understood, but neuroendocrine factors seem to be of major importance. Studies of familial association suggest that genetic factors play a role in FMS. This study will establish patterns of genetic linkage in families with FMS.

Participating family members will undergo a brief physical exam (including tender point exam), donate a blood sample, and complete a detailed questionnaire that includes experience with pain, fatigue, depression, bowel symptoms, headache, anxiety, and physical limitations. Measurements of serum serotonin and related compounds will also be obtained. To detect genetic factors, a genome-wide linkage scan using 405 microsatellite markers will be performed.

Observational
Observational Model: Family-Based
Time Perspective: Retrospective
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Retention:   Samples With DNA
Description:

DNA, whole blood

Probability Sample

The population of this study is family based and aimed to recruit 160 multic-case FMS families. We plan to perform a genome scan and evaluate 200-300 linkage markers to FMS and FMS-related traits. Future plans include establishing a DNA and data repository for distribution for future studies.

  • Fibromyalgia
  • Irritable Bowel Syndrome
  • Chronic Fatigue Syndrome
  • Depression
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Yunus MB, Khan MA, Rawlings KK, Green JR, Olson JM, Shah S. Genetic linkage analysis of multicase families with fibromyalgia syndrome. J Rheumatol. 1999 Feb;26(2):408-12.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
560
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Inclusion Criteria

  • Diagnosed with fibromyalgia according to the criteria of the American College of Rheumatology
  • Have at least one living family member who has also been diagnosed with fibromyalgia
  • No other major rheumatological disease
Both
12 Years and older
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00071162
NIAMS-100
No
Sudha Iyengar, PhD, Case Western Reserve University
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Not Provided
Study Chair: Sudha Iyengar, PhD Case Western Reserve University
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
March 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP