Brain Cell Injury in Patients With A First Episode of Psychosis

This study has been completed.
Sponsor:
Information provided by:
National Center for Complementary and Alternative Medicine (NCCAM)
ClinicalTrials.gov Identifier:
NCT00070889
First received: October 9, 2003
Last updated: August 17, 2006
Last verified: July 2006

October 9, 2003
August 17, 2006
September 1999
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Complete list of historical versions of study NCT00070889 on ClinicalTrials.gov Archive Site
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Brain Cell Injury in Patients With A First Episode of Psychosis
Oxidative Cell Injury: First Episode Psychotic Patients

Patients experiencing a first episode of psychosis may have brain cell damage due to a chemical process called oxidation. This study will compare patients with psychosis to healthy volunteers to determine if there are differences in their blood that reflect oxidative brain cell damage.

Preliminary research indicated that impaired antioxidant defense and increased lipid peroxidation is associated with brain changes during the onset of psychosis. Oxidative cell injury may contribute to poor outcomes in some patients. This study will define the extent and nature of oxidative cell injury that is associated with psychopathology at the onset of psychosis.

Participants in this study will be patients at the D. D. Eisenhower Army Medical Center who are experiencing a psychotic episode for the first time. Patients will be compared with 40 healthy volunteers (control group) matched with patients for age, gender, education, ethnic background, and occupational status. Patients and volunteers will have blood tests to determine the level of oxidative cell injury. Tests will be performed at onset of psychosis, and after 6 and 12 weeks of neuroleptic drug treatment. Medical histories and MRI scans will be used to examine the relationship of the laboratory tests to the clinical presentation.

Observational
Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal
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Psychoses
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
30
August 2004
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Inclusion Criteria

  • Patients must meet clinical diagnostic criteria for psychosis
  • Healthy (control) volunteers must not have any family history of mental illness
Both
12 Years to 45 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00070889
R01 AT000147-01
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National Center for Complementary and Alternative Medicine (NCCAM)
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Principal Investigator: Sahebrao P. Mahadik, PhD Georgia Regents University
National Center for Complementary and Alternative Medicine (NCCAM)
July 2006

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP