Therapy for Depression With Co-occurring Panic or Anxiety Symptoms

This study has been completed.
Sponsor:
Information provided by:
University of Pittsburgh
ClinicalTrials.gov Identifier:
NCT00051207
First received: January 7, 2003
Last updated: June 21, 2013
Last verified: December 2007

January 7, 2003
June 21, 2013
November 2002
Not Provided
Not Provided
Not Provided
Complete list of historical versions of study NCT00051207 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Therapy for Depression With Co-occurring Panic or Anxiety Symptoms
Interpersonal Psychotherapy for Depression With Co-occurring Panic and Anxiety Symptoms (IPT-PS)

This 6-month study, with a 3-month follow up period, will compare the effectiveness of new and traditional psychotherapies for depression with panic or anxiety symptoms.

Many depressed patients also experience significant symptoms of panic or anxiety. This study will compare the effectiveness of a new therapy called interpersonal psychotherapy for depression with panic or anxiety symptoms (IPT-PS) with that of traditional interpersonal psychotherapy for depression (IPT).

Participants are randomly assigned to receive up to 24 weeks of treatment with either IPT-PS or traditional IPT. Improvements in interpersonal functioning, quality of life, and symptoms of depression and anxiety will be assessed at the end of therapy and at a 3-month follow-up.

Interventional
Phase 1
Phase 2
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
  • Depression
  • Anxiety Disorders
  • Panic Disorder
  • Behavioral: Interpersonal Psychotherapy (IPT)
  • Behavioral: IPT for Depression with Co-occurring Panic and Anxiety Symptoms (IPT-PS)
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
36
August 2005
Not Provided

Inclusion Criteria:

  • DSM-IV diagnosis of major depression with co-existing panic or anxiety symptoms.

Exclusion Criteria:

  • History of manic episode(s). Patients who have had hypomanic episodes in the past will be accepted into the study, provided they meet other admission criteria and are not presenting in a current hypomanic or mixed episode.
  • History of schizophrenia or schizoaffective disorder.
  • Organic affective syndrome.
  • Unspecified functional psychosis.
  • Anorexia nervosa or bulimia nervosa. Patients meeting criteria for an eating disorder not otherwise specified will not be excluded.
  • Chronic drug or alcohol abuse/dependence within the past 2 years. Patients with abuse related to episodes will not be excluded.
  • DSM-IV criteria for borderline or antisocial personality disorder. Patients who meet criteria for other Axis II disorders will not be excluded.
  • Inpatient treatment due to suicide risk or psychotic symptoms.
  • Index episode secondary to the effect of medically prescribed drugs.
  • Significant or untreated medical illness, including cardiovascular disorder, renal or liver disease, epilepsy, untreated hypertension, or unstabilized endocrine disease.
  • Medical illness that would interfere with the best treatment strategy for the potential participant.
  • Current treatment with an antidepressant. Patients on a stable dose of anxiolytics for at least 3 months prior to study participation who are able to maintain this dosage throughout the study will not be excluded.
  • Pregnant and breast-feeding women will be accepted into the study, but will not be prescribed adjunctive medications.
Both
18 Years to 60 Years
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00051207
R21 MH61948, DSIR AT-AS
Not Provided
Not Provided
University of Pittsburgh
Not Provided
Not Provided
University of Pittsburgh
December 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP