Enhanced Tactile (Touch) Spatial Acuity in Upper Limb Amputees

This study has been completed.
Sponsor:
Information provided by:
National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:
NCT00028210
First received: December 17, 2001
Last updated: March 3, 2008
Last verified: March 2004

December 17, 2001
March 3, 2008
December 2001
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Complete list of historical versions of study NCT00028210 on ClinicalTrials.gov Archive Site
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Enhanced Tactile (Touch) Spatial Acuity in Upper Limb Amputees
Enhancement of Tactile Spatial Acuity in Upper Limb Amputees

This study will examine whether tactile (touch) abilities at the lip are more acute in people with upper limb amputation compared with healthy normal volunteers. People with an amputated upper limb have an expanded brain representation of the lip that may correlate with heightened tactile spatial acuity.

Normal volunteers will be recruited for this study. Candidates will be screened with physical and neurological examinations. (Amputee volunteers will be studied at the amputee clinic at the University of Tubingen, Germany.)

Participants will sit comfortably in a chair, wearing a blindfold, during the following experiments:

  • Plastic domes with grooves are placed on parts of the lower lip on either side for a few seconds. The volunteer is then asked to identify the direction of the grooves relative to the long axis of the lip.
  • The participant's arm is placed in a cast and the index finger is immobilized. The same test done on the lip is repeated on the distal part of the index finger.

Each part of the test lasts about 20 minutes, and the entire experiment takes about 2 hours.

Upper limb amputation leads to expansion of the cortical representation of the lip into the adjacent deafferented hand representation. It is conceivable that this enlargement of the lip representation may translate into a behavioral gain. The purpose of this protocol is to test the hypothesis that upper limb amputation in humans results in higher tactile spatial acuity at the lip. This would represent the first demonstration of chronic deafferentation-induced behavioral gains within the somatosensory system.

Observational
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Amputation
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
60
March 2004
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INCLUSION CRITERIA:

Normal volunteers who are willing and able to stay relaxed and collaborative for a period of up to 2 hours.

Subjects with upper limb amputation more than one year before testing.

EXCLUSION CRITERIA:

Neurological or psychiatric disease

Excessive callus at the palm of the fingers

Subjects, who are unable to perform or understand the task

Both
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Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00028210
020067, 02-N-0067
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National Institute of Neurological Disorders and Stroke (NINDS)
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National Institutes of Health Clinical Center (CC)
March 2004

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP