Lipitor as a Treatment for Alzheimer's Disease

This study has been completed.

Sponsor:

Collaborator:

Pfizer

Information provided by:

National Institute on Aging (NIA)

ClinicalTrials.gov Identifier:

NCT00024531

First received: September 19, 2001

Last updated: November 8, 2006

Last verified: November 2006

History of Changes

Tracking Information

First Received Date ^ICMJE

September 19, 2001

Last Updated Date

November 8, 2006

Start Date ^ICMJE

October 2000

Primary Completion Date

Not Provided

Current Primary Outcome Measures ^ICMJE

Not Provided

Original Primary Outcome Measures ^ICMJE

Not Provided

Change History

Complete list of historical versions of study NCT00024531 on ClinicalTrials.gov Archive Site

Current Secondary Outcome Measures ^ICMJE

Not Provided

Original Secondary Outcome Measures ^ICMJE

Not Provided

Current Other Outcome Measures ^ICMJE

Not Provided

Original Other Outcome Measures ^ICMJE

Not Provided

Descriptive Information

Brief Title ^ICMJE

Lipitor as a Treatment for Alzheimer's Disease

Official Title ^ICMJE

Effect of the HMG-CoA Reductase Inhibitor Atorvastatin Calcium, Lipitor, in the Treatment of Alzheimer's Disease

Brief Summary

The purpose of this study is to assess the clinical benefit of Lipitor, a cholesterol-lowering drug, in the treatment of Alzheimer's disease.

Detailed Description

This study is a phase II, placebo controlled, double-blind, one year trial investigating the effect of HmG-CoA reductase inhibitor atorvastatin calcium in the treatment of persons with possible or probable Alzheimer's disease. Subjects may continue to take stable doses of Aricept and Exelon. Following enrollment, participants will make visits to the study center every three months for blood tests and neuropsychological testing.

Study Type ^ICMJE

Interventional

Study Phase

Phase 2

Study Design ^ICMJE

Allocation: Randomized
Endpoint Classification: Efficacy Study
Masking: Double-Blind
Primary Purpose: Treatment

Condition ^ICMJE

Alzheimer Disease

Intervention ^ICMJE

Drug: Atorvastatin calcium

Study Arm (s)

Not Provided

Publications *

* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.

Recruitment Information

Recruitment Status ^ICMJE

Completed

Enrollment ^ICMJE

Completion Date

August 2004

Primary Completion Date

Not Provided

Eligibility Criteria ^ICMJE

Inclusion Criteria:

Prior to participation in this study, each prospective study individual must sign an informed consent form.
Diagnosis of probable or possible Alzheimer's disease according to NINDS-ADRDA and DSM-IV criteria.
Not actively participating in another clinical drug trial.
MMSE range 12-28 at entry.
Hachinski Modified Ischemic score < or =4.
Accompanied by appropriate caregiver who can aid in administration of medication and make assessments.
Good general health as evidenced by physical, neurological and clinical laboratory examination.
Education level > or = 9th grade or equivalent.
Fluent in the English language.
Reliable caregiver.
Able to complete neuropsychological tests.
Ambulatory.
On stable doses of medications for the treatment of non-excluded medical conditions for four weeks prior to screening.
Able to participate in all scheduled evaluations.
Geriatric Depression Scale < or = 20.
Not exceeding 400 IU of Vitamin E for 30 days.
For patients currently taking donepezil, they must remain on a stable dose for at least three months. Individuals taking stable doses of other cholinesterase inhibitors can be included, but no study subject may initiate use of any cholinesterase inhibitor after entrance to trial.
Individuals of both sexes over 50 years of age will be eligible.

Exclusion criteria:

Significant neurological or psychiatric disease other than Alzheimer's disease.
Patients with known or suspected Parkinsons's disease or dementia with Lewy bodies.
Significant systemic illness (including uncontrolled hypertension) or organ failure.
History of mental illness within one year or history of significant untreated cardiac or thromboembolic vascular disease (arrythmias, unstable angina, CVA, deep venous thrombosis, or pulmonary embolus).
Current chronic use of anti-cholinergic medications (anti-histamines, and Artane or Cogentin). Stable doses of anxiolytics, sedatives, hypnotics, antipsychotics and SSRI antidepressants are acceptable. The use of any antipsychotics or tricyclic anti-depressants must be reviewed prior to entry.
Diagnosis of major depression according to DSM-IV criteria in the last two years.
Allergies to atorvastatin or HMG CoA reductase inhibitors.
Pregnant women.
History of head injury.
On a cholesterol lowering drug at time of enrollment.
History of significant liver disease and or elevated transaminases.
Cholesterol level lower than 90 mg% at initial screening

Gender

Both

Ages

50 Years and older

Accepts Healthy Volunteers

Contacts ^ICMJE

Contact information is only displayed when the study is recruiting subjects

Location Countries ^ICMJE

United States

Administrative Information

NCT Number ^ICMJE

NCT00024531

Other Study ID Numbers ^ICMJE

IA0031

Has Data Monitoring Committee

Not Provided

Responsible Party

Not Provided

Study Sponsor ^ICMJE

Institute for the Study of Aging (ISOA)

Collaborators ^ICMJE

Pfizer

Investigators ^ICMJE

Principal Investigator:

David L Sparks, PhD

Sun Health Research Institute

Information Provided By

National Institute on Aging (NIA)

Verification Date

November 2006

^ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP

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