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Quetiapine vs Haloperidol Decanoate for the Long Term Treatment of Schizophrenia and Schizoaffective Disorder

This study has been completed.
Sponsor:
Information provided by:
Department of Veterans Affairs
ClinicalTrials.gov Identifier:
NCT00018642
First received: July 3, 2001
Last updated: January 20, 2009
Last verified: December 2004

July 3, 2001
January 20, 2009
April 1997
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Complete list of historical versions of study NCT00018642 on ClinicalTrials.gov Archive Site
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Quetiapine vs Haloperidol Decanoate for the Long Term Treatment of Schizophrenia and Schizoaffective Disorder
Predicting the Optimal Pharmacotherapy for Outpatients With Schizophrenia

The purpose of this research study is to determine whether a new drug for schizophrenia is better for the maintenance treatment than a standard drugs currently prescribed. The new medication is called quetiapine and it will be compared with a standard medication called haloperidol decanoate. The study will determine if quetiapine causes fewer problems than haloperidol with side effects such as stiffness and restlessness and whether it costs the VA more or less to treat patients with quetiapine. In addition, blood samples will be collected every three months to determine if certain chemicals in the blood can influence the outcome of the subjects' illness.

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Interventional
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Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Primary Purpose: Treatment
  • Schizophrenia
  • Schizoaffective Disorder
  • Drug: quetiapine
  • Drug: haloperidol decanoate
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
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March 2002
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Inclusion Criteria

  1. Schizophrenia or Schizoaffective Disorder diagnosed by DSM-IV
  2. Between the ages 18-60.
  3. A candidate for maintenance antipsychotic therapy. This means that patients will have had at least two documented episodes of acute schizophrenic illness or at least two years of continuing psychotic symptoms.

Exclusion Criteria

  1. Organic brain disease.
  2. Mental Retardation
  3. Chronic medical illness which would make antipsychotic medication inappropriate.
Both
18 Years to 60 Years
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00018642
MHBS-042-96F
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Department of Veterans Affairs
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Department of Veterans Affairs
December 2004

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP