Osteoporosis in Children and Adults Following Liver Transplantation

The recruitment status of this study is unknown because the information has not been verified recently.
Verified December 2003 by National Center for Research Resources (NCRR).
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by:
National Center for Research Resources (NCRR)
ClinicalTrials.gov Identifier:
NCT00008788
First received: January 16, 2001
Last updated: June 23, 2005
Last verified: December 2003

January 16, 2001
June 23, 2005
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Complete list of historical versions of study NCT00008788 on ClinicalTrials.gov Archive Site
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Osteoporosis in Children and Adults Following Liver Transplantation
Osteoporosis in Children and Adults Following Liver Transplantation

This pilot project aims to 1) estimate the prevalence of osteoporosis in adults having undergone liver transplantation in childhood, and 2) identify risk factors for osteoporosis in this group. We aim to study 40 individuals.

Background: Osteoporosis is defined as an absolute decrease in the amount of bone (volume and/or density). Chronic liver disease is associated with osteoporosis in both adults and children. Bone density is also decreased in the months immediately after liver transplantation, but improves to pretransplant values after 1 to 2 years. Immunosuppressive agents, most notably steroids, are a cause of osteoporosis. However, studies on adults have shown that bone densities afer transplantation continue to improve within the normal range for healthy adults. In the case of children, bone accretion is necessary for growth. Chronic liver disease and transplantation in childhood will have an adverse effect on bone metabolism and the outcome in terms of bone density after the growth period cannot be predicted on individuals transplanted as adults or other transplant groups.

Observational
Observational Model: Defined Population
Time Perspective: Cross-Sectional
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  • Osteoporosis
  • Liver Transplantation
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
40
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  • Liver transplantation in childhood or young adulthood
Both
16 Years to 40 Years
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00008788
NCRR-M01RR00400-0664
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National Center for Research Resources (NCRR)
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National Center for Research Resources (NCRR)
December 2003

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP