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| Descriptive Information Fields | |
| Brief Title † | Molecular Genetics of Schizophrenia |
| Official Title † | |
| Brief Summary | This study will create a DNA collection with blood samples from families with at least two siblings who have schizophrenia symptoms. This collection will help scientists identify genes that predispose people to schizophrenia. |
| Detailed Description | Each site will recruit individuals in a large geographic area, and use efficient ascertainment strategies and assessment procedures in order to maximize the number collected. Subjects thought to have schizophrenia will be assessed by personal and family interviews and a review of medical records. Diagnoses will be made by consensus best-estimate procedures. Blood specimens will be obtained from all individuals with schizophrenia or schizoaffective disorder plus their available parents and also the control individuals. A clinical self-assessment will be administered to each control subject. The assessment will include validated self-assessments of lifetime major depression, anxiety disorders, and substance use, and self-reported history of bipolar or psychotic symptoms. Permanent cell lines will be created and DNA extracted at the NIMH-sponsored Center for Genetic Studies. At the end of the four-year project period, biological materials and blinded pedigree and clinical data will be made available to the scientific community for genetic studies of schizophrenia and related disorders. The control sample will, however, be released in a staggered fashion, twice during each fiscal year, to start during the 2nd year of recruitment. The informed consent for controls includes consent for specimens to be used in research on the genetics of any medical disorder. In years 3 and 4, we will undertake association analyses. Power analyses suggest that this study will have excellent power to detect loci associated with genes with relatively small etiologic effects. Data derived from this study will potentially have applications for the treatment and prevention of schizophrenia. |
| Study Phase | |
| Study Type † | Observational |
| Study Design † | Natural History |
| Primary Outcome Measure † | |
| Secondary Outcome Measure † | |
| Condition † | Schizophrenia |
| Intervention † | Procedure: DNA collection |
| MEDLINE PMIDs | |
| Links | National Institute of Mental Health Center for Genetic Studies  |
| Recruitment Information Fields | |
| Recruitment Status † | Recruiting |
| Enrollment † | 10800 |
| Start Date † | September 2003 |
| Completion Date | August 2007 |
| Eligibility Criteria † | Inclusion Criteria:
Exclusion Criteria:
|
| Gender | Both |
| Ages | 18 Years and older |
| Accepts Healthy Volunteers | No |
| Contacts †† | |
| Location Countries † | United States, Australia |
| Administrative Information Fields | |
| NCT ID † | NCT00006418 |
| Organization ID | R01 MH59571 |
| Secondary IDs †† | R01 MH59571, R01 MH59588, R01 MH60870, R01 MH59565, R01 MH59566, R01 MH60879, R01 MH59586, R01 MH61675, R01 MH59587, DNBBS 7G-GRR |
| Study Sponsor † | National Institute of Mental Health (NIMH) |
| Collaborators †† | |
| Investigators † | |
| Information Provided By | National Institute of Mental Health (NIMH) |
| Verification Date | November 2005 |
| First Received Date † | October 25, 2000 |
| Last Updated Date | November 18, 2005 |
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