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Effects of Exercise on Markers of Inflammation in Skeletal Muscle in Elderly Hip Fracture Patients

This study has been completed.
Study NCT00006194.   Last updated on June 23, 2005.   Information provided by National Center for Research Resources (NCRR)

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Descriptive Information Fields
Brief Title  Effects of Exercise on Markers of Inflammation in Skeletal Muscle in Elderly Hip Fracture Patients
Official Title 
Brief Summary

Decreased skeletal muscle mass is a prevalent condition among the elderly, and an important cause of disability and functional decline. The declines in muscle mass associated with aging may be related to alterations in specific kinds of growth factors in the muscle. Elderly hip fracture patients often have significant decreases in muscle mass. The purpose of this study is to investigate whether an exercise program can induce changes in muscle growth factors that are associated with increases in muscle mass and strength in elderly hip fracture patients.

Detailed Description
Study Phase
Study Type  Interventional
Study Design  Treatment, Randomized, Single Group Assignment
Primary Outcome Measure 
Secondary Outcome Measure 
Condition  Hip Fractures
Muscular Atrophy
Intervention  Behavioral: Exercise
MEDLINE PMIDs
Links
Recruitment Information Fields
Recruitment Status  Completed
Enrollment 
Start Date 
Completion Date
Eligibility Criteria 

Inclusion Criteria:

  • Enrollment in HSC protocol #97-0695 "Rehabilitation Intensification Post Hip Fracture"
  • Community-dwelling
  • Hip fracture within 16 weeks of the screening assessment for protocol 97-0695
  • Persistent mobility and/or ADL impairments, but independent in ambulation
  • Modified Physical Performance Test (PPT) score between 12 and 28
Gender Both
Ages 65 Years and older
Accepts Healthy Volunteers No
Contacts ††
Location Countries  United States
Administrative Information Fields
NCT ID  NCT00006194
Organization ID NCRR-M01RR00036-0764
Secondary IDs †† M01RR00036
Study Sponsor  National Center for Research Resources (NCRR)
Collaborators ††
Investigators 
Information Provided By National Center for Research Resources (NCRR)
Verification Date December 2003
First Received Date  September 7, 2000
Last Updated Date June 23, 2005

 †    Required WHO trial registration data element.
††   WHO trial registration data element that is required only if it exists.




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