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Genetic Study of Familial Epilepsy

This study has been completed.
Sponsor:
Collaborator:
Columbia University
Information provided by:
National Center for Research Resources (NCRR)
ClinicalTrials.gov Identifier:
NCT00006059
First received: July 5, 2000
Last updated: June 23, 2005
Last verified: December 2003

July 5, 2000
June 23, 2005
January 1997
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Complete list of historical versions of study NCT00006059 on ClinicalTrials.gov Archive Site
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Genetic Study of Familial Epilepsy
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OBJECTIVES:

I. Determine the chromosomal regions that contain genes that raise the risk of epilepsy in families by performing genetic linkage analysis of idiopathic/cryptogenic epilepsy.

PROTOCOL OUTLINE: Family histories are obtained, then the patients undergo an interview, a neurological examination, and EEG. Blood specimens are also collected.

Linkage analysis is performed on specimens and analysis of shared marker alleles are used to identify genomic regions likely or unlikely to contain the epilepsy genes. Genotypes in family members are determined at microsatellite markers throughout the genome. Markers tested include chromosomes linked to human epilepsy syndromes (6p, 8p, 8q, 20q, 21q) and chromosome 3 (similar to mouse "epilepsy" genes). Linkage to markers on chromosome 10q are also tested.

Patients do not receive the results of the testing and the results do not influence the type and duration of any treatment.

Observational
Primary Purpose: Screening
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Epilepsy
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
898
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PROTOCOL ENTRY CRITERIA:

--Disease Characteristics--

Male or female members of families with at least 1 close relative pair (sibling, half sibling, avuncular, grandparent-grandchild, or first cousin) affected with idiopathic/cryptogenic epilepsy that developed before age 25

Both
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Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00006059
NCRR-M01RR00645-2635, CPMC-IRB-4465
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National Center for Research Resources (NCRR)
Columbia University
Study Chair: Ruth Ottman Columbia University
National Center for Research Resources (NCRR)
December 2003

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP