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| Descriptive Information Fields | |||||||||
| Brief Title † | Evaluation of Patients With Endocrine-Related Conditions | ||||||||
| Official Title † | Evaluation of Patients With Endocrine-Related Conditions | ||||||||
| Brief Summary | This study will evaluate patients with a variety of endocrine disorders in order to 1) learn more about conditions that affect the endocrine glands (glands that secrete hormones) and 2) to train physicians in endocrinology. Patients of all ages with endocrine-related conditions may be eligible for evaluation under this protocol. Those enrolled may be required to provide blood, saliva, urine or stool samples, and to undergo ultrasound examination of the thyroid gland, ovaries or testes, adrenal glands or other parts of the body. Laboratory or X-ray studies may be done for diagnostic or treatment purposes. In some cases, patients will receive medical or surgical treatment for their disorder. Patients and family members of patients with a hereditary disorder may be asked to provide a blood sample for genetic analysis. |
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| Detailed Description | This protocol is designed to allow inpatient and outpatient evaluation of patients with a variety of endocrine disorders for purposes of research and physician education in our accredited endocrinology training programs, and to allow for small pilot studies in normal volunteers. The research-directed evaluations may include blood, saliva, urine or stool samples, and/or ultrasound examinations. In some patients with endocrine disorders, laboratory or radiological studies will be performed to confirm the diagnosis or to aid in the management of the patient, as would be done in current clinical practice. In some cases, the patient will receive medical or surgical treatment for their disorder. The purpose of these evaluations or treatments will be to support our clinical training or research missions. |
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| Study Phase | |||||||||
| Study Type † | Observational | ||||||||
| Study Design † | |||||||||
| Primary Outcome Measure † | |||||||||
| Secondary Outcome Measure † | |||||||||
| Condition † | Endocrine Disease Glucose Intolerance Hyperinsulinemia Impaired Glucose Tolerance Non Insulin Dependent Diabetes Mellitus Obesity Type II Diabetes Mellitus |
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| Intervention † | |||||||||
| MEDLINE PMIDs | |||||||||
| Links | NIH Clinical Center Detailed Web Page  |
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| Recruitment Information Fields | |||||||||
| Recruitment Status † | Recruiting | ||||||||
| Enrollment † | 1500 | ||||||||
| Start Date † | May 2000 | ||||||||
| Completion Date | |||||||||
| Eligibility Criteria † |
Patients of all ages with endocrine-related conditions will be eligible for this protocol. EXCLUSION CRITERIA: Unstable patients and patients with severe organ failure that may affect/limit the endocrine work-up and exhaust Clinical Center and/or NICHD resources will be excluded. Hematologic abnormalities: platelets less than 100,000 cells/mm(3), hemoglobin less than 10 mg/dl and/or WBC less than 3,000 cells/mm(3). Cardiovascular disorders: Clinical evidence of congestive heart failure, unstable angina. Hepatic/Renal Dysfunction: Severe hepatic insufficiency (SGOT, SGPT, alkaline phosphatase, total bilirubin) greater than 200% of the upper limit of normal); serum creatinine greater than 2.0 mg/dl. Respiratory distress: Ventilator-dependent patients. Advanced and/or multiple non-endocrine disorders. |
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| Gender | Both | ||||||||
| Ages | |||||||||
| Accepts Healthy Volunteers | No | ||||||||
| Contacts †† |
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| Location Countries † | United States | ||||||||
| Administrative Information Fields | |||||||||
| NCT ID † | NCT00005664 | ||||||||
| Organization ID | 000127 | ||||||||
| Secondary IDs †† | 00-CH-0127 | ||||||||
| Study Sponsor † | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | ||||||||
| Collaborators †† | |||||||||
| Investigators † | |||||||||
| Information Provided By | National Institutes of Health Clinical Center (CC) | ||||||||
| Verification Date | April 2008 | ||||||||
| First Received Date † | May 17, 2000 | ||||||||
| Last Updated Date | July 18, 2008 | ||||||||
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