Gene Mapping for Quantitative Traits

This study has been completed.
Sponsor:
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier:
NCT00005535
First received: May 25, 2000
Last updated: June 23, 2005
Last verified: October 2002

May 25, 2000
June 23, 2005
September 1995
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Complete list of historical versions of study NCT00005535 on ClinicalTrials.gov Archive Site
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Gene Mapping for Quantitative Traits
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To conduct gene mapping studies for quantitative traits.

DESIGN NARRATIVE:

The study built upon existing sib-pair methods for multipoint mapping of Quantitative Trait Loci (QTL)s. It greatly expanded upon the statistical methodology to identify and localize QTLs for complex traits by merging sib-pair methods with a powerful twin design which used phenotypic data on monozygotic (identical) and dizygotic (fraternal) twins to resolve phenotypic variability into genetic and non-genetic components, and partition human quantitative genetic variation into effects due to loci on specific chromosomal regions. This quantitative methodology was applied to risk factors for cardiovascular disease -- one of the most pressing health problems in Western society. Population-based samples of Dutch, Swedish, and Australian twins had been identified in previous studies, phenotypic measures on lipids, lipoproteins, and other important cardiovascular risk factors had been obtained, and blood had been banked in a valuable resource which was available for use in this study. In 500 DZ twin pairs, a series of 175 highly polymorphic microsatellite markers were detected using an automated process for detecting fluorescent signals. These data were analyzed using the new statistical methods both to confirm the effects of a series of candidate loci and to test for the effects of previously unknown QTLs.

Observational
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  • Cardiovascular Diseases
  • Heart Diseases
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
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August 2000
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No eligibility criteria

Both
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Contact information is only displayed when the study is recruiting subjects
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NCT00005535
5068
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National Heart, Lung, and Blood Institute (NHLBI)
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Investigator: George Vogler Penn State University
National Heart, Lung, and Blood Institute (NHLBI)
October 2002

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP